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Valuing the endangered species Antirrhinum lopesianum: neuroprotective activities and strategies for in vitro plant propagation

2013Journal article Open access
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dc.contributor.authorGomes, Andreia Karla
dc.contributor.authorFortalezas, Sofia
dc.contributor.authorPimpão, Rui
dc.contributor.authorFigueira, Inês
dc.contributor.authorMaroco, João
dc.contributor.authorAguiar, Carlos
dc.contributor.authorFerreira, Ricardo B.
dc.contributor.authorMiguel, Célia
dc.contributor.authorSantos, Cláudia N.
dc.date.accessioned2014-10-27T09:54:33Z
dc.date.available2014-10-27T09:54:33Z
dc.date.issued2013
dc.description.abstractPlant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration. Antirrhinum lopesianum is a rare endemism from the Iberian Peninsula, occurring at the northeastern border between Portugal and Spain. It is classified as Endangered, due to its highly fragmented geographical occupation, facing a high risk of extinction in the Portuguese territory, within 20 years. Here, we describe for the first time the chemical characterization of extracts of the species concerning total phenol content, flavonoid content and antioxidant properties. The profile of high performance liquid chromatography with diode array detector (HPLC-DAD) of the polyphenol-enriched fraction of plant extracts was also performed, showing the great potential of the species as a source of bioactive phytochemical compounds. A. lopesianum’s potential for neuroprotection was revealed by a significant acetylcholinesterase inhibitory activity and also by a neuroprotective effect on a human cell model of neurodegeneration. Moreover, this is the first report describing a successful procedure for the in vitro propagation of this endangered species. The comparison of phenolic content and the HPLC-DAD profile of wild and in vitro propagated plants revealed that in vitro plants maintain the ability to produce secondary metabolites, but the profiles are differentially affected by the growth regulators. The results presented here greatly contribute to the value for this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits.por
dc.identifier.citationGomes, A.; Fortalezas, S.; Pimpão, R.; Figueira, I.; Maroco, J.; Aguiar, C.; Ferreira, R.; Miguel, C.; Santos, C. (2013). Valuing the endangered species Antirrhinum lopesianum: neuroprotective activities and strategies for in vitro plant propagation. Antioxidants. ISSN 2076-3921. 2:4, p. 273-292por
dc.identifier.doi10.3390/antiox2040273
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10198/11028
dc.language.isoporpor
dc.peerreviewedyespor
dc.relationNEUROPROTECTIVE EFFECTS ON A NEURODEGENERATION CELL MODEL EXHIBITED BY SERUM BIOAVAILABLE METABOLITES OBTAINED FROM A HUMAN INTERVENTION STUDY WITH HIGHLY ANTIOXIDANT FRUITS
dc.relationDECIPHERING THE POTENTIAL OF BLACKBERRY POLYPHENOLS FOR PARKINSON DISEASE: DIGESTION, BLOOD BRAIN BARRIER TRANSPOSITION AND NEUROPROTECTIVE EFFECT
dc.subjectAntirrhinum lopesianumpor
dc.subjectPhytochemical profilepor
dc.subjectAntioxidant capacitypor
dc.subjectNeuroprotectionpor
dc.subjectAcetylcholinesterase inhibitorpor
dc.subjectEx situ conservationpor
dc.titleValuing the endangered species Antirrhinum lopesianum: neuroprotective activities and strategies for in vitro plant propagationpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNEUROPROTECTIVE EFFECTS ON A NEURODEGENERATION CELL MODEL EXHIBITED BY SERUM BIOAVAILABLE METABOLITES OBTAINED FROM A HUMAN INTERVENTION STUDY WITH HIGHLY ANTIOXIDANT FRUITS
oaire.awardTitleDECIPHERING THE POTENTIAL OF BLACKBERRY POLYPHENOLS FOR PARKINSON DISEASE: DIGESTION, BLOOD BRAIN BARRIER TRANSPOSITION AND NEUROPROTECTIVE EFFECT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F84618%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F63615%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F86584%2F2012/PT
oaire.citation.titleAntioxidantspor
oaire.fundingStreamSFRH
person.familyNameAguiar
person.givenNameCarlos
person.identifier.ciencia-id5912-C8F4-7686
person.identifier.orcid0000-0001-8643-7112
person.identifier.ridI-3933-2014
person.identifier.scopus-author-id54413830100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublication.latestForDiscoverye0f72c9d-ad86-44ee-a41e-c02a70dc6336
relation.isProjectOfPublication4b559aa8-5479-4b77-9afb-cfe963951887
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