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Doxorubicin delivery performance of superparamagnetic carbon multi-core shell nanoparticles: pH dependence, stability and kinetic insight

2022Journal article Open access
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dc.contributor.authorSilva, Adriano S.
dc.contributor.authorDíaz de Tuesta, Jose Luis
dc.contributor.authorSayuri Berberich, Thais
dc.contributor.authorInglez, Simone Delezuk
dc.contributor.authorBertão, Ana Raquel
dc.contributor.authorÇaha, Ihsan
dc.contributor.authorDeepak, Francis Leonard
dc.contributor.authorBañobre-López, Manuel
dc.contributor.authorGomes, Helder
dc.date.accessioned2022-05-25T09:36:21Z
dc.date.available2022-05-25T09:36:21Z
dc.date.issued2022
dc.description.abstractIn the past decade, magnetic nanoparticles (MNPs) have been among the most attractive nanomaterials used in different fields, such as environmental and biomedical applications. The possibility of designing nanoparticles with different functionalities allows for advancing the biomedical applications of these materials. Additionally, the magnetic characteristics of the nanoparticles enable the use of magnetic fields to drive the nanoparticles to the desired sites of delivery. In this context, the development of new MNPs in new approaches for drug delivery systems (DDSs) for cancer treatment has increased. However, the synthesis of nanoparticles with high colloidal stability triggered drug delivery, and good biocompatibility remains a challenge. Herein, multi-core shell MNPs functionalized with Pluronic ® F-127 were prepared and thoroughly characterized as drug carriers for doxorubicin delivery. The functionalized nanoparticles have an average size of 17.71 ± 4.2 nm, high water colloidal stability, and superparamagnetic behavior. In addition, the nanoparticles were able to load 936 μg of DOX per mg of functionalized nanomaterial. Drug release studies at different pH values evidenced a pH-triggered DOX release effect. An increase of 62% in cumulative drug release was observed at pH simulating tumor endosome/lysosome microenvironments (pH 4.5) compared to physiological conditions (pH 7.4). In addition, an innovative dynamic drug delivery study was performed as a function of pH. The results from this test confirmed the pH-induced doxorubicin release capability of carbon multi-core shell MNPs. The validity of traditional kinetic models to fit dynamic pH-dependent drug release was also studied for predictive purposes.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and to the ERDF for financial support by funds FCT/MCTES to CIMO (UIBD/00690/2020) and RTChip4Theranostics (NORTE-01-0145-FEDER-029394). This work is a result of these projects. This research was funded by RTChip4Theranostics – Real time Liver-on-a-chip platform with integrated micro(bio)sensors for preclinical validation of graphene-based magnetic nanocarriers towards cancer theranostics, with the reference NORTE-01-0145-FEDER-029394, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); and CIMO (UIDB/00690/2020) through ERDF under the Program PT2020. Adriano S. Silva thanks his doctoral Grant with reference SFRH/BD/151346/2021 financed by the Portuguese Foundation for Science and Technology (FCT), with funds from NORTE2020, under the MIT Portugal Program.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1039/D1NR08550Fpt_PT
dc.identifier.urihttp://hdl.handle.net/10198/25541
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationUIBD/00690/2020pt_PT
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSolution combustionpt_PT
dc.subjectSynthesis magneticpt_PT
dc.subjectParticlespt_PT
dc.subjectDrug-deliverypt_PT
dc.subjectReleasept_PT
dc.subjectDesignpt_PT
dc.subjectMatrixpt_PT
dc.subjectEnergypt_PT
dc.titleDoxorubicin delivery performance of superparamagnetic carbon multi-core shell nanoparticles: pH dependence, stability and kinetic insightpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F151346%2F2021/PT
oaire.citation.endPage7232pt_PT
oaire.citation.issue19pt_PT
oaire.citation.startPage7220pt_PT
oaire.citation.titleNanoscalept_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameSilva
person.familyNameDíaz de Tuesta
person.familyNameGomes
person.givenNameAdriano S.
person.givenNameJose Luis
person.givenNameHelder
person.identifier.ciencia-id3E14-5049-B09D
person.identifier.ciencia-id7A1F-022B-7DBF
person.identifier.ciencia-id6218-1E19-13EE
person.identifier.orcid0000-0002-6795-2335
person.identifier.orcid0000-0003-2408-087X
person.identifier.orcid0000-0001-6898-2408
person.identifier.ridD-9785-2017
person.identifier.scopus-author-id55755821600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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