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Flow of red blood cells through microchannel with a confluence

2011Conference paper Open access
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dc.contributor.authorVladimir, Leble
dc.contributor.authorLima, Rui A.
dc.contributor.authorFernandes, Carla S.
dc.contributor.authorDias, Ricardo P.
dc.date.accessioned2012-06-26T09:08:07Z
dc.date.available2012-06-26T09:08:07Z
dc.date.issued2011
dc.description.abstractOver the years micro-visualization techniques have been used to investigate in vitro blood flow through straight microchannels with dimensions close to in vivo capillaries. However, a few detailed studies have been performed in complex in vitro microvascular networks composed by diverging and converging bifurcations. The main purpose of present work is to show the application of a confocal micro-PTV system to track both flourescent particles and red blood cells (RBCs) through a rectangular polydimethysiloxane (PDMS) microchannel with a confluence. The measurements of the flow behaviour of trace particles suspended in pure water and RBCs in concentrated suspensions were performed in the surroundings of a confluence. After performing simulations with the commercial finite element software package POLYFLOW®, some experimental results were compared with the numerical ones. Experimental results for pure water were in a good agreement with numerical results. Overall, the RBCs velocities were higher than those for fluorescent particles which suggest that RBC deformability and cell-free layer formation around the apex of the confluence may play an important role on the observed deviationspor
dc.description.sponsorshipThe authors acknowledge the financial support provided by: PTDC/SAU-BEB/108728/2008 and PTDC/EME-MFE/099109/2008 from the FCT (Science and Technology Foundation) and COMPETE, Portugal.
dc.identifier.citationVladimir, Leble; Lima, R.; Fernandes, Carla S.; Dias, Ricardo P. (2011). Flow of red blood cells through microchannel with a confluence. In Congress on Numerical Methods in Engineering 2011. Coimbrapor
dc.identifier.urihttp://hdl.handle.net/10198/7066
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.subjectRed blood cellspor
dc.subjectVelocity profilespor
dc.subjectConfocal micro-PTVpor
dc.subjectConfluencepor
dc.subjectMicrochannelpor
dc.titleFlow of red blood cells through microchannel with a confluencepor
dc.typeconference paper
dspace.entity.typePublication
oaire.awardTitleHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F108728%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
oaire.citation.conferencePlaceCoimbrapor
oaire.citation.titleCongress on Numerical Methods in Engineering 2011por
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNameLima
person.familyNameFernandes
person.familyNameDias
person.givenNameRui A.
person.givenNameCarla S.
person.givenNameRicardo P.
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.ciencia-idF319-3D67-9DB7
person.identifier.orcid0000-0003-3428-637X
person.identifier.orcid0000-0002-3138-7493
person.identifier.orcid0000-0003-1503-998X
person.identifier.ridH-5157-2016
person.identifier.ridA-4269-2015
person.identifier.scopus-author-id18437397800
person.identifier.scopus-author-id8253740700
person.identifier.scopus-author-id7102885151
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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