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Modelling dissolution of sparingly soluble powders
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Resumo(s)
The present work deals with the simulation of the dissolution process of polydisperse powders. Three different size fractions of Ibuprofen were used to develop a model which assumes a diffusion layer thickness proportional to the particle diameter, up to a critical value, beyond which it is considered constant. The application of the resultant integrated equations to each size
class of the primary particle size distribution leads to an almost perfect
agreement between simulated and experimental dissolution profiles.
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Citação
Almeida, Luís Pereira de; Brito, Paulo; Sousa, A.; Portugal, António; Figueiredo, Margarida (1997). Modelling dissolution of sparingly soluble powders. In European Symposium on Formulation of Poorly-Available Drugs for Oral Administration. Paris. p. 243-246.