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Progesterone-loaded solid lipid nanoparticles for use in the regulation of the estrous cycle in female rats

2023Journal article Restricted access
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dc.contributor.authorFogolari, Odinei
dc.contributor.authorLeimann, Fernanda Vitória
dc.contributor.authorIneu, Rafael Porto
dc.contributor.authorRudy, Marcia
dc.contributor.authorLudwig, André Franco
dc.contributor.authorSalles, Fernando Marques
dc.contributor.authorAmorim, João Paulo de Arruda
dc.contributor.authorFranci, Celso Rodrigues
dc.contributor.authorSagae, Sara Cristina
dc.contributor.authorSayer, Claudia
dc.contributor.authorAraújo, Pedro Henrique Hermes de
dc.contributor.authorGonçalves, Odinei Hess
dc.date.accessioned2023-12-19T09:57:50Z
dc.date.available2023-12-19T09:57:50Z
dc.date.issued2023
dc.description.abstractProtocols used for artificial insemination involve the effective synchronization of the estrous cycle by the administration of exogenous hormones including progesterone analogs. Although widespread in the world, the current techniques present many disadvantages that need to be overcome such as the time dependency of progesterone levels in the blood and the need to remove the release dispositive. Nanotechnology may offer the tools for it, and solid lipid nanoparticles (SLN) are a promising candidate to be used as nanocarriers for progesterone. In this work, progesterone-loaded SLNs were investigated in the regulation of the estrous cycle in female rats. First, the obtention of the SLN was investigated to determine how experimental parameters may affect the encapsulation efficiency of progesterone and the morphology of the nanoparticles. Also, in vitro release profiles of progesterone were also evaluated. Sexual receptivity, mutagenicity, hepatic inflammation and steatosis, hormone measurement, and biometric parameters of pups were also determined. Progesterone-loaded SLN induced estrous cycle synchronization and were able to maintain the estrous phase of the estrous cycle while inducing a greater latency release for its onset. Progesterone induced an increase in the sexual receptivity of the females and did not alter the biometric parameters like the body weight of the mothers and puppies, until weaning. Results gathered here demonstrated that encapsulation of progesterone may be a promising alternative to the conventional methods for synchronization of the estrous cycle of female animals in artificial insemination procedures.pt_PT
dc.description.sponsorshipThis study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. Authors also thank CNPq and Fundação Araucária (039/2019) and FAPESP for the financial support.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFogolari, Odinei; Leimann, Fernanda Vitória; Ineu, Rafael Porto; Rudy, Marcia; Ludwig, André Franco; Salles, Fernando Marques; Amorim, João Paulo de Arruda; Franci, Celso Rodrigues; Sagae, Sara Cristina; Sayer, Claudia; Araújo, Pedro Henrique Hermes de; Gonçalves, Odinei Hess (2023). Progesterone-loaded solid lipid nanoparticles for use in the regulation of the estrous cycle in female rats. Journal of Drug Delivery Science and Technology. ISSN 1773-2247. 88, p. 1-8pt_PT
dc.identifier.doi10.1016/j.jddst.2023.104954pt_PT
dc.identifier.eissn2588-8943
dc.identifier.issn1773-2247
dc.identifier.urihttp://hdl.handle.net/10198/28968
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEditions de Santept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSLNpt_PT
dc.subjectNanoencapsulationpt_PT
dc.subjectFixed-time artificial inseminationpt_PT
dc.subjectEstrous cycle synchronizationpt_PT
dc.titleProgesterone-loaded solid lipid nanoparticles for use in the regulation of the estrous cycle in female ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Drug Delivery Science and Technologypt_PT
oaire.citation.volume88pt_PT
person.familyNameLeimann
person.familyNameGonçalves
person.givenNameFernanda Vitória
person.givenNameOdinei Hess
person.identifier.ciencia-id8F10-A04D-FC0D
person.identifier.orcid0000-0001-6230-9597
person.identifier.orcid0000-0002-9528-8187
person.identifier.scopus-author-id9335958400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb1102a0b-38dc-4caa-baed-ad52ccd9b230
relation.isAuthorOfPublication84c8eea0-77bb-4c18-b9d8-46f865980706
relation.isAuthorOfPublication.latestForDiscoveryb1102a0b-38dc-4caa-baed-ad52ccd9b230

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