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Pickering emulsions stabilized with chitosan/gum arabic particles: effect of chitosan degree of deacetylation on the physicochemical properties and cannabidiol (CBD) topical delivery

2022Journal article Open access
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dc.contributor.authorSharkawy, Asma
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorRodrigues, Alírio
dc.date.accessioned2022-05-18T10:28:36Z
dc.date.available2022-05-18T10:28:36Z
dc.date.issued2022
dc.description.abstractPickering emulsions (PEs) have recently gained increasing attention as green carriers of bioactive agents due to their surfactant-free and eco-friendly nature. Herein, the effect of the degree of deacetylation (DDA) of chitosan on the properties of chitosan/gum Arabic (CH/GA) particles and PEs was investigated. CH/GA particles with a DDA of 96% (high DDA) and 78% (low DDA) were prepared. The contact angle of water drop for the CH/GA particles prepared with high and low DDA chitosan was 84.2 and 77.5 , respectively. The dynamic interfacial tension of the particles has shown lower values with high DDA chitosan. The high DDA PE formulation exhibited higher stability after two months of storage than its counterpart prepared with low DDA chitosan. The mean emulsion droplet size was 15.6 ± 4.3 mm and 21.1 ± 2.6 mm for PEs prepared with high and low DDA chitosan, respectively. Both PE formulations demonstrated shear thinning and elastic gel-like properties. The amount of cannabidiol absorbed by the stratum corneum, viable epidermis and dermis was significantly higher in both PE formulations than the permeated amount, but no significant difference was observed between the amounts absorbed from both formulations.pt_PT
dc.description.sponsorshipThis work was financially supported by the Base- UIDB/50020/2020 and Programmatic- UIDP/50020/2020 Funding of LSRE-LCM, funded by national funds through FCT/MCTES (PIDDAC), and the Base Funding – UIDB/00690/2020 of CIMO – Centro de Investigação de Montanha – funded by national funds through FCT/MCTES (PIDDAC). The authors gratefully acknowledge the technical support of the i3S, University of Porto. Asma Sharkawy acknowledges the Foundation for Science and Technology (FCT, Portugal) for the doctoral scholarship (PD/BD/135085/2017). The authors are extremely thankful to Filipa M. Casimiro and Dr. Carina Costa (at the LSRE, University of Porto) for the invaluable technical help. The graphical abstract was created using BioRender.com, with a publication license.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSharkawy, Asma; Barreiro, M.F.; Rodrigues, Alírio (2022). Pickering emulsions stabilized with chitosan/gum Arabic particles: Effect of chitosan degree of deacetylation on the physicochemical properties and cannabidiol (CBD) topical delivery. Journal of Molecular Liquids. EISSN 0167-7322. 355, p. 1-9pt_PT
dc.identifier.doi10.1016/j.molliq.2022.118993pt_PT
dc.identifier.eissn0167-7322
dc.identifier.urihttp://hdl.handle.net/10198/25476
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationDevelopment and characterization of encapsulation systems for the protection and controlled release of active agents
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChitosanpt_PT
dc.subjectDegree of deacetylationpt_PT
dc.subjectPickering emulsionspt_PT
dc.subjectEmulsion stabilitypt_PT
dc.subjectCannabidiolpt_PT
dc.subjectTopical drug deliverypt_PT
dc.titlePickering emulsions stabilized with chitosan/gum arabic particles: effect of chitosan degree of deacetylation on the physicochemical properties and cannabidiol (CBD) topical deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleDevelopment and characterization of encapsulation systems for the protection and controlled release of active agents
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F135085%2F2017/PT
oaire.citation.startPage118993pt_PT
oaire.citation.titleJournal of Molecular Liquidspt_PT
oaire.citation.volume355pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreiro
person.givenNameFilomena
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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