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Combined exercise hinders the progression of pulmonary and right heart harmful remodeling in monocrotaline-induced pulmonary arterial hypertension

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dc.contributor.authorLeite, Luciano Bernardes
dc.contributor.authorSoares, Leôncio Lopes
dc.contributor.authorPortes, Alexandre Martins Oliveira
dc.contributor.authorSilva, Bruna Aparecida Fonseca da
dc.contributor.authorDias, Taís Rodrigues
dc.contributor.authorSoares, Thayana Inácia
dc.contributor.authorAssis, Mirian Quintão
dc.contributor.authorGuimarães-Ervilha, Luiz Otávio
dc.contributor.authorCarneiro-Júnior, Miguel Araújo
dc.contributor.authorForte, Pedro
dc.contributor.authorMachado-Neves, Mariana
dc.contributor.authorReis, Emily Correna Carlo
dc.contributor.authorNatali, Antônio José
dc.date.accessioned2025-02-04T10:41:15Z
dc.date.available2025-02-04T10:41:15Z
dc.date.issued2025
dc.description.abstractThe aim of this study was to test whether combined physical exercise training of moderate intensity executed during the devel- opment of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) hinders the progression of pulmonary and right heart harmful functional and structural remodeling in rats. Wistar rats were injected with MCT (60 mg/kg) and after 24 h were exposed to a combined exercise training program: aerobic exercise (treadmill running—60 min/day; 60% of maximum running speed); and resistance exercise (vertical ladder climbing—15 climbs; 60% of maximum carrying load), on alternate days, 5 days/ wk, for 3 wk. After euthanasia, the lung and right ventricle (RV) were excised and processed for histological, single myocyte, and biochemical analyses. Combined exercise increased the tolerance to physical effort (time until fatigue and relative maximum load) and prevented increases in pulmonary artery resistance (acceleration time (TA)/ejection time (TE)] and reductions in RV function [tricuspid annular plane systolic excursion (TAPSE)]. Moreover, in myocytes isolated from the RV, combined exercise pre- served contraction amplitude, as well as contraction and relaxation velocities, and inhibited reductions in the amplitude and max- imum speeds to peak and to decay of the intracellular Ca2 þ transient. Furthermore, combined exercise avoided RV (RV weight, cardiomyocyte, extracellular matrix, collagen, inflammatory infiltrate, and extracellular matrix) and lung (pulmonary alveoli and al- veolar septum) harmful structural remodeling. In addition, combined exercise restricted RV [nitric oxide (NO) and carbonyl protein (CP)] and lung [catalase (CAT), glutathione S-transferase (GST), and NO] oxidative stress. In conclusion, the applied combined exercise regime hinders the progression of pulmonary and right heart functional and structural harmful remodeling in rats with MCT-induced PAH.pt_PT
dc.description.sponsorshipL. B. Leite is thankful to Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brazil (CAPES) for the scholarship. A. J. Natali and M. Machado-Neves are thankful to CNPq—Brazil for the fellowships. This work was supported by the Fundação de Amparo à Pesquisa do Estado de Minas Gerais—Brasil (FAPEMIG)—Grant No. APQ-01485-22, Conselho Nacional de Desenvolvimento Científico e Tecnologico—Brasil (CNPq)—Grant No. 306956/2021-7, and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) – Finance Code 001.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLeite, Luciano Bernardes; Soares, Leôncio Lopes; Portes, Alexandre Martins Oliveira; Silva, Bruna Aparecida Fonseca da; Dias, Taís Rodrigues; Soares, Thayana Inácia; Assis, Mirian Quintão; Guimarães-Ervilha, Luiz Otávio; Carneiro-Júnior, Miguel Araújo; Forte, Pedro; Machado-Neves, Mariana; Reis, Emily Correna Carlo; Natali, Antônio José (2025). Combined exercise hinders the progression of pulmonary and right heart harmful remodeling in monocrotaline-induced pulmonary arterial hypertension. Journal of Applied Physiology. ISSN 8750-7587. 138: 1, p. 182-194pt_PT
dc.identifier.doi10.1152/japplphysiol.00379.2024pt_PT
dc.identifier.eissn1522-1601
dc.identifier.issn8750-7587
dc.identifier.urihttp://hdl.handle.net/10198/31117
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Physiological Societypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCombined exercise trainingpt_PT
dc.subjectIsolated myocytespt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPulmonary arterial hypertensionpt_PT
dc.subjectRemodelingpt_PT
dc.subjectResearch Subject Categories::INTERDISCIPLINARY RESEARCH AREAS::Sportspt_PT
dc.titleCombined exercise hinders the progression of pulmonary and right heart harmful remodeling in monocrotaline-induced pulmonary arterial hypertensionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage194pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage182pt_PT
oaire.citation.titleJournal of Applied Physiologypt_PT
oaire.citation.volume138pt_PT
person.familyNameForte
person.givenNamePedro
person.identifier.ciencia-id351B-B16B-79C7
person.identifier.orcid0000-0003-0184-6780
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0
relation.isAuthorOfPublication.latestForDiscovery3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0

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