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Blueberry Extract and Resistance Training Prevent Left Ventricular Redox Dysregulation and Pathological Remodeling in Experimental Severe Pulmonary Arterial Hypertension

2025Journal article Open access
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datacite.subject.fosCiências Sociais::Ciências da Educação
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLeite, Luciano Bernardes
dc.contributor.authorSoares, Leôncio Lopes
dc.contributor.authorGuimarães-Ervilha, Luiz Otávio
dc.contributor.authorCosta, Sebastião Felipe Ferreira
dc.contributor.authorGeneroso, Sara Caco dos Lúcio
dc.contributor.authorXavier, Mirielly Alexia Miranda
dc.contributor.authorIasbik-Lima, Thainá
dc.contributor.authorOliveira, Leandro Licursi
dc.contributor.authorLucia, Ceres Mattos Della
dc.contributor.authorBianchi, Sara Elis
dc.contributor.authorBassani, Valquíria Linck
dc.contributor.authorHerter, Flavio Gilberto
dc.contributor.authorTurck, Patrick
dc.contributor.authorAraujo, Alex Sander da Rosa
dc.contributor.authorForte, Pedro
dc.contributor.authorReis, Emily Correna Carlo
dc.contributor.authorMachado-Neves, Mariana
dc.contributor.authorNatali, Antônio José
dc.date.accessioned2025-06-11T10:42:19Z
dc.date.available2025-06-11T10:42:19Z
dc.date.issued2025
dc.description.abstractTo investigate whether the regular administration of blueberry extract and low-intensity resistance exercise training (RT), either alone or in combination, during the development of monocrotaline (MCT)-induced severe pulmonary arterial hypertension (PAH) in rats protect the left ventricle (LV) from redox dysregulation and pathological remodeling. Groups of seven male Wistar rats were formed for the experiment: sedentary control; sedentary hypertensive; sedentary hypertensive blueberry; exercise hypertensive; and exercise hypertensive blueberry. PAH was experimentally induced through a single intraperitoneal administration of MCT at a dose of 60 mg/kg. One day after injection, the blueberry groups started receiving a daily dose of blueberry extract (100 mg/kg) by gavage, while the exercise groups initiated a three-week program of RT (ladder climbing; 15 climbs carrying 60% of maximum load; one session/day; 5 times/week). Echocardiographic evaluations were conducted 23 days after injection, and the rats were euthanized the next day to harvest LV tissue. Separately, blueberry extract and RT mitigated augments in pulmonary artery resistance, LV tissue redox dysregulation (i.e., increased PC levels) and detrimental remodeling (i.e., reduced inflammation), and reductions in ejection fraction (EF) and fractional shortening (FS) caused by PAH. The combination of treatments prevented reductions in EF and FS, along with the development of a D-shaped LV. blueberry extract and moderate-intensity resistance training administered during the development of MCT-induced severe PAH in rats prevented LV redox dysregulation and pathological remodeling, thereby preserving its function.eng
dc.description.sponsorshipThis study was funded by the Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Brazil (grant numbers APQ-01485-22 and BPD-00060-22); the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil (grant number 306956/2021-7); and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), which provided a scholarship to L.B.L. (finance code 001). The funding agencies were not involved in this study’s design, data collection, analysis, or interpretation, the writing of the manuscript, or the decision to submit it for publication.
dc.identifier.citationLeite, Luciano Bernardes; Soares, Leôncio Lopes; Guimarães-Ervilha, Luiz Otávio; Costa, Sebastião Felipe Ferreira; Generoso, Sara Caco dos Lúcio; Xavier, Mirielly Alexia Miranda; Iasbik-Lima, Thainá; Oliveira, Leandro Licursi; Lucia, Ceres Mattos Della; Bianchi, Sara Elis; Bassani, Valquíria Linck; Herter, Flavio Gilberto; Turck, Patrick; Araujo, Alex Sander da Rosa; Forte, Pedro; Reis, Emily Correna Carlo; Machado-Neves, Mariana; Natali, Antônio José (2025). Blueberry Extract and Resistance Training Prevent Left Ventricular Redox Dysregulation and Pathological Remodeling in Experimental Severe Pulmonary Arterial Hypertension. Nutrients. ISSN 2072-6643. 17:7, p. 1-17
dc.identifier.doi10.3390/nu17071145
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10198/34574
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.ispartofNutrients
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPulmonary artery resistance
dc.subjectExercise training
dc.subjectLeft ventricle
dc.subjectRedox state
dc.subjectEjection fraction
dc.subjectAdverse remodeling
dc.subjectBlueberry extract
dc.titleBlueberry Extract and Resistance Training Prevent Left Ventricular Redox Dysregulation and Pathological Remodeling in Experimental Severe Pulmonary Arterial Hypertensioneng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferenceDate2025
oaire.citation.endPage17
oaire.citation.issue7
oaire.citation.startPage1
oaire.citation.titleNutrients
oaire.citation.volume17
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameForte
person.givenNamePedro
person.identifier.ciencia-id351B-B16B-79C7
person.identifier.orcid0000-0003-0184-6780
relation.isAuthorOfPublication3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0
relation.isAuthorOfPublication.latestForDiscovery3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0

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