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Association between bilirubin and lipid profile in Portuguese elderly individuals

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dc.contributor.authorGomes, Ana
dc.contributor.authorRodrigues, Carina
dc.contributor.authorFernandes, Adília
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorRebelo, Irene
dc.date.accessioned2017-01-16T16:53:18Z
dc.date.available2017-01-16T16:53:18Z
dc.date.issued2016
dc.description.abstractSeveral studies showed that mildly elevated bilirubin blood concentration is inversely associated to coronary artery disease (CAD). The most commonly mechanism contributing to CAD prevention is the bilirubin antioxidant effect, protecting several macromolecules from oxidation. Recently, other studies have found that higher serum bilirubin levels (BL) are associated with beneficial effects improving lipid profile and that might contribute to decrease cholesterol and triacylglycerol. In the meantime, a consistently negative association between BL and body mass index (BMI) was observed. The aim of this study was evaluate the cardiovascular risk protection by bilirubin analyzing the association between bilirubin levels and lipid profile in elderly. Clinical data, anthropometric measurements (BMI, Visceral Fat and Body Fat Percentage), lipid profile (total cholesterol-TC; triglycerides-TG; high-density lipoprotein cholesterol-HDL-c; low-density lipoprotein cholesterol-LDL-c; apoliprotein A-Apo-A; apoliprotein B-Apo-B) were evaluated in 70 institutionalized elderly, 43 females (mean age= 88.2±5.5 years old) and 27 males (mean age= 87.7±7.7 years old). Anthropometric measurements were obtained by bioimpedance, using specific scale (Tanita BC Model: 545). The lipid parameters were performed in autoanalyzer (Cobas Mira S, Roche, Switzerland) using available commercial kits. Correlation analysis revealed positive associations between BL and the HDL-c in males (total bilirubin: r=0.51; p<0.007) and no association in females (r=0.40; p<0.50). Positive associations were also found to TB levels and Apo-A (males: r=0.40; p<0.50 and females: r=0.270; p<0.013). Interestingly, the conjugated bilirubin present a stronger positive association with this two parameters (male: r=0.64; p<0.000; female: r=0.29; p<0.052). No associations were found between bilirubin and triglycerides; total cholesterol and anthropometric measurements. Low levels of HDL-c are a risk factor for coronary heart disease. A similar association has been shown for Apo-A1. These results suggest higher bilirubin is associated with higher cardioprotective agents, which indicates that the determination of total bilirubin should be included for more accurate cardiovascular disease risk assessment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, Ana; Rodrigues; Carina; Fernandes, Adília; Vaz, Josiana A.; Rebelo, Irene (2016). Association between bilirubin and lipid profile in Portuguese elderly individuals. In I Congresso Nacional e I Encontro Nacional de Estudantes Ciências Biomédicas Laboratoriais. Bragançapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/13814
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Politécnico de Bragança, Escola Superior de Saúdept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBilirubin levelspt_PT
dc.subjectLipid profilept_PT
dc.subjectCardioprotectivept_PT
dc.subjectPreventionpt_PT
dc.titleAssociation between bilirubin and lipid profile in Portuguese elderly individualspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBragançapt_PT
oaire.citation.titleIn I Congresso Nacional | I Encontro Nacional de Estudantes Ciências Biomédicas Laboratoriais. Bragançapt_PT
person.familyNameRodrigues
person.familyNameFernandes
person.familyNameVaz
person.givenNameCarina
person.givenNameAdília
person.givenNameJosiana A.
person.identifier.ciencia-idC415-C677-0253
person.identifier.ciencia-id0514-76CD-8CCF
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.orcid0000-0001-9773-1413
person.identifier.orcid0000-0003-1658-4509
person.identifier.orcid0000-0002-6989-1169
person.identifier.ridV-8399-2017
person.identifier.scopus-author-id56489572200
person.identifier.scopus-author-id16305323200
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationef666665-6593-48be-bc48-6a1bb58bedbd
relation.isAuthorOfPublicationbdfceda8-18d6-4b63-b6f9-d3870cd0dbb0
relation.isAuthorOfPublication1c1a2cb9-5a36-47ba-bca0-ffcbef28df18
relation.isAuthorOfPublication.latestForDiscoverybdfceda8-18d6-4b63-b6f9-d3870cd0dbb0

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