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Phenolic profile and effects of acetone fractions obtained from the inflorescences of Calluna vulgaris (L.) Hull on vaginal pathogenic and non-pathogenic bacteria

2019Artigo científico Acesso aberto
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dc.contributor.authorMandim, Filipa
dc.contributor.authorBarros, Lillian
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorAlves, Maria José
dc.contributor.authorSantos, Paulo F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-03T10:35:26Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-03T10:35:26Z
dc.date.issued2019
dc.description.abstractThe phenolic profile and the antibacterial activity against pathogenic commensal vaginal bacteria exhibited by different fractions of the acetone extract of heather was assessed. The acetone extract of Calluna vulgaris (L.) Hull was fractionated by silica gel column chromatography through an eluent system of increasing polarity, obtaining 10 different fractions (Fr 1 to Fr 10). The phenolic profile was analyzed by HPLCDAD- ESI/MS. Type B (epi)catechin dimers, (-)-epicatechin and (+)-catechin were the main phenolic compounds present in the fractions. The antibacterial activity was also analyzed against pathogenic bacteria and the effect in the beneficial microflora was also accessed. Some of the obtained fractions revealed the capacity to inhibit pathogenic microorganisms without affecting the beneficial microflora, especially Fr 7 and Fr 8. For instance, Neisseria gonorrhoeae was inhibited by both of the fractions, while Fr 7 was more active against Klebsiella pneumoniae and Morganella morganii, and Fr 8 against methicillin resistance Staphylococcus aureus (MRSA) and methicillin susceptible Staphylococcus aureus (MSSA), without affecting Lactobacillus strains. This study corroborates the therapeutic use of this matrix in traditional medicine.
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programmer PT2020 for financial support to CIMO (UID/AGR/00690/2019), CQ-VR (UID/QUI/00616/2013), and to FEDER-Interreg España-Portugal program for financial support through the project 0377_Iberphenol_6_E. The authors are also grateful to the Foundation for Science and Technology (FCT, Portugal) for Sandrina A. Heleno (SFRH/BPD/101413/2014) grant and L. Barros contract.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationMandim, Filipa; Barros, Lillian; Heleno, Sandrina A.; Pires, Tânia C.S.P.; Dias, Maria Inês; Alves, Maria José; Santos, Paulo F.; Ferreira, Isabel C.F.R. (2019). Phenolic profile and effects of acetone fractions obtained from the inflorescences of: Calluna vulgaris (L.) Hull on vaginal pathogenic and non-pathogenic bacteria. Food and Function. ISSN 2042-6496. 10, p. 2399-2407en_EN
dc.identifier.doi10.1039/c9fo00415gen_EN
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/19983
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.titlePhenolic profile and effects of acetone fractions obtained from the inflorescences of Calluna vulgaris (L.) Hull on vaginal pathogenic and non-pathogenic bacteriaen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/QUI/00616/2013
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00616%2F2013/PT
oaire.fundingStream5876
person.familyNameMandim
person.familyNameBarros
person.familyNameHeleno
person.familyNamePires
person.familyNameDias
person.familyNameAlves
person.familyNameFerreira
person.givenNameFilipa
person.givenNameLillian
person.givenNameSandrina A.
person.givenNameTânia C.S.P.
person.givenNameMaria Inês
person.givenNameMaria José
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier2118829
person.identifier144781
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-id321E-2D96-00CA
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridL-5951-2014
person.identifier.ridQ-2842-2018
person.identifier.ridM-8242-2013
person.identifier.ridM-6624-2016
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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