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Phenolic composition and biological activities of the in vitro cultured endangered Eryngium viviparum J. Gay

2020Journal article Open access
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dc.contributor.authorAyuso, Manuel
dc.contributor.authorPinela, José
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorIvanov, Marija
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSoković, Marina
dc.contributor.authorRamil-Rego, Pablo
dc.contributor.authorBarreal, M. Esther
dc.contributor.authorGallego, Pedro Pablo
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-06-22T10:18:15Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-06-22T10:18:15Z
dc.date.issued2020
dc.description.abstractEryngium viviparum is an endangered species that requires management efforts based on complementary ex situ conservation strategies, such as in vitro culture. This study was carried out to evaluate the phenolic composition and the antioxidant, cytotoxic, and antimicrobial properties of E. viviparum aerial and root parts obtained by this micropropagation technique. The HPLC-DAD-ESI/MSn analysis showed that phenolic compounds were more abundant in the root (102 ± 4 mg g−1 extract) than in the aerial part (40.6 ± 0.8 mg g−1 extract) of the plant. The major compound was trans rosmarinic acid, followed by trans 3-O-caffeoylquinic acid. The root extract also showed higher antioxidant activity, with a result close to that of trolox in the thiobarbituric acid reactive substances (TBARS) formation inhibition assay, and a moderate toxicity to lung (NCI-H460), breast (MCF-7) and liver (HepG2) tumour cells. It was also more effective than ketoconazole against Penicillium ochrochloron. In turn, the aerial part extract inhibited Salmonella typhimurium more effectively than ampicillin. This study highlights E. viviparum as an unexplored source of bioactive compounds with potential application in the food, pharmaceutical, and other industrial sectors. Consequently, it promotes the interest of conserving this endangered species.
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and the research contracts of J. Pinela, M.I. Dias, R.C. Calhelha, and L. Barros (national funding by FCT, P.I., through the institutional scientific employment program-contract). To the FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E. To the project TRANSCoLAB: 0612_TRANS_CO_LAB_2_P. This work was also supported by Xunta de Galicia, Spain (CITACA Strategic Partnership, Reference: ED431E 2018/07), “Red de Uso Sostenible de Recursos y Residuos” (ED431D 2017/18), and the Research Stay Grant of Manuel Ayuso from IACOBUS program.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationAyuso, Manuel; Pinela, José; Dias, Maria Inês; Barros, Lillian; Ivanov, Marija; Calhelha, Ricardo C.; Soković, Marina; Ramil-Rego, Pablo; Barreal, M. Esther; Gallego, Pedro Pablo; Ferreira, Isabel C.F.R. (2020). Phenolic composition and biological activities of the in vitro cultured endangered Eryngium viviparum J. Gay. Industrial Crops and Products. ISSN 0926-6690. 148, p. 1-7en_EN
dc.identifier.doi10.1016/j.indcrop.2020.112325en_EN
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/21579
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationED431E 2018/07
dc.subjectApiaceaeen_EN
dc.subjectBioactive propertiesen_EN
dc.subjectEx situ conservationen_EN
dc.subjectHerbal plantsen_EN
dc.subjectIn vitro cultureen_EN
dc.subjectPhenolic acidsen_EN
dc.titlePhenolic composition and biological activities of the in vitro cultured endangered Eryngium viviparum J. Gayen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameAyuso
person.familyNamePinela
person.familyNameDias
person.familyNameBarros
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameManuel
person.givenNameJosé
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifierABC-7764-2020
person.identifier469085
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person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-1697-3857
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridB-4466-2014
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54392272800
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person.identifier.scopus-author-id35236343600
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person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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