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Rosa canina L. as new food ingredient an source of bioactive compounds

2017Conference object Open access
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dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-12T14:51:58Z
dc.date.available2018-02-12T14:51:58Z
dc.date.issued2017
dc.description.abstractSustainable food options are increasing among the most concerned consumers, in which they seek to combine new ingredients with potential health benefits [1]. Edible flowers provide new colors, textures and vibrancy to any dish, and apart from the "glam" factor, they can provide bioactive compounds [2]. In the presentwork, the edible petals of Rosa canina L, gently supplied by the RBR Foods Company (Portugal), were tested for their cytotoxic activity against tumor cell lines. The assays were conducted in the hydromethanolic extract and in the lyophilized infusion, being both of them re-dissolved in water in order to obtain stock solutions at 100 mg/mL for successive dilutions until determination of Glso values (concentration that inhibits 50% of the net cell growth). Four human tumor cell lines were tested: MCF-7 (breast adenocarcinoma), NCIH460 (non-small cell lung câncer), HeLa (cervical carcinoma) and HepG2 (hepatocellular carcinoma). A non-tumour primary cells' culture (assigned as PLP2) was also prepared from a freshly harvested porcine liver, and used in the bioassays. Ellipticine was used as the positive contrai. While the hydromethanolic extract inhibited the growth of HeLa (308 pg/mL), the lyophilized infusion inhibited MCF-7 (377 pg/mL), respectively. Both extracts presented cytotoxicity for HepG2 (297 |jg/mL and 315 pg/mL for hydromethanolic extract and infusion, respectively). Nane of the extracts showed toxicity towards PLP2. After chemical characterization of the extracts, flavonoids were the only phenolic compounds present, being quercetin-3-O-glucoside and kaempferol-3-O-glucoside the major compounds present in both extracts. These results showed that R. canina edible flowers are sources of bioactive compounds related with cytotoxic properties in human tumor cell lines, highlighting their applicability potential in nutraceutical and pharmaceutical fields.pt_PT
dc.description.sponsorshipThe authors are grateful to lhe Foundation for Science and Technology (FCT, Portugal) and FEDER under Pmgramme PT2020 for financial support to CIMO (UID/AGR/00690/2013). L. Barras (SFR/BPD/107855/2015) and M. l. Dias (SFRH/BD/84485/2012) grants.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPires, Tânia C.S.; Dias, Maria Inês; Barros, Lillian; Calhelha, Ricardo; Oliveira, M.B.P.P.; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2017). Rosa canina L. as new food ingredient an source of bioactive compounds. In 3rd Symposium on Medicinal Chemistry of University of Minho. Bragapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/15685
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationSFR/BPD/107855/2015pt_PT
dc.relationIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleRosa canina L. as new food ingredient an source of bioactive compoundspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F84485%2F2012/PT
oaire.citation.conferencePlaceBraga, Portugalpt_PT
oaire.citation.title3rd Symposium on Medicinal Chemistry of University of Minhopt_PT
oaire.fundingStream5876
person.familyNamePires
person.familyNameDias
person.familyNameBarros
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameTânia C.S.P.
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier2118829
person.identifier469085
person.identifier144781
person.identifier.ciencia-id321E-2D96-00CA
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person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridQ-2842-2018
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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