| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 4.04 MB | Adobe PDF |
Advisor(s)
Abstract(s)
This work proposes the application of a new electroencephalogram (EEG) signal processing tool - the lacsogram - to characterize the Alzheimer’s disease (AD) activity and to assist on its diagnosis at different stages: Mild Cognitive Impairment (MCI), Mild and Moderate AD (ADM) and Advanced AD (ADA). Statistical analyzes are performed to lacstral distances between conventional EEG subbands to find measures capable of discriminating AD in all stages and characterizing the AD activity in each electrode. Cepstral distances are used for comparison. Comparing all AD stages and Controls (C), the most important significances are the lacstral distances between subbands and (p=0.0014<0.05). The topographic maps show significant differences in parietal, temporal and frontal regions as AD progresses. Machine learning models with a leave-one-out cross-validation process are applied to lacstral/cepstral distances to develop an automatic method for diagnosing AD. The following classification accuracies are obtained with an artificial neural network: 95.55% for All vs All, 98.06% for C vs MCI, 95.99% for C vs ADM, 93.85% for MCI vs ADM-ADA. In C vs MCI, C vs ADM and MCI vs ADM-ADA, the proposed method outperforms the stateof- art methods by 5%, 1%, and 2%, respectively. In All vs All, it outperforms the state-of-art EEG and non-EEG methods by 6% and 2%, respectively. These results indicate that the proposed method represents an improvement in diagnosing AD.
Description
Keywords
Alzheimer’s disease Mild-cognitive impairment Diagnose Artificial neural networks Cepstrum Lacsogram
Citation
Rodrigues, Pedro M.; Bispo, Bruno C.; Garrett, Carolina ; Alves, Dilio; Teixeira, Joao Paulo; Freitas, Diamantino (2021). Lacsogram: a new EEG tool to diagnose Alzheimer's disease. IEEE Journal of Biomedical and Health Informatics. 25:9, p. 3384 3395
Publisher
IEEE Journal of Biomedical and Health Informatics