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Bioactivity and chemical characterization of phenolic and anthocyanin extracts of Arbutus unedo L. wild fruits

2013Conference object Open access
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dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-09-10T08:34:09Z
dc.date.available2013-09-10T08:34:09Z
dc.date.issued2013
dc.description.abstractPhenolic metabolites are common constituents of fruits and vegetables, and the interest of plant phenolic extracts derives from the evidence of their potent antioxidant activity and their wide range of pharmacologic properties including anticancer, antimicrobial and platelet aggregation inhibition activities. The fruits of Arbutus unedo L. are eaten raw or made in liqueurs (1 ]. In traditional folk medicine, they are reported as having antiseptic, diuretic and laxative effects, being also used to treat arterial hypertension (2) .Moreover, the bark or roots decoctions are used as anti-inflammatory, laxative, carminative, digestive, odontalgic and cardiotonic. In this work, two different enriched phenolic extracts were prepared from A. unedo frutis, in order to evaluate and compare their bioactivity: a phenolic extract without anthocyanins (PE; with phenolic acids, flavones/ols, flavan-3-ols and galloyl derivatives) and a separate anthocyanins extract (AE). A. unedo PE presented the highest antioxidant activity in all the in vitro assays (free radicals scavenging activity, reducing power and lipid peroxidation inhibition), which could be related to the presence of galloyl derivatives. The antiproliferation activity was tested in different human tumour cell lines (breast, lung, colon, cervical and hepatocellular carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture (PLP2). A. unedo PE also gave the highest antiproliferation inhibition presenting a Gl50 value=38 119/ml for NCI-H460- non-small lung carcinoma cell line, without toxicity for PLP2 (GI 50>400 119/m l). Overall, the results showed that A. unedo fruits may have great potential for food industries as a source of colors and flavors, as well as bioactive molecules such as phenolic compounds for dietary supplements or functional foods.por
dc.identifier.citationGuimarães, Rafaela; Barros, Lillian; Calhelha, Ricardo C.; Dueñas, Montserrat; Carvalho, Ana Maria; Queiroz, Maria-João R.P.; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2013). Bioactivity and chemical characterization of phenolic and anthocyanin extracts of Arbutus unedo L. wild fruits. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8694
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationPEstOE/AGR/UI0690/2011
dc.relationStrategic Project - UI 686 - 2011-2012
dc.relationSFRH/BPD/4609/2008
dc.titleBioactivity and chemical characterization of phenolic and anthocyanin extracts of Arbutus unedo L. wild fruitspor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 686 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FQUI%2FUI0686%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F78307%2F2011/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minhopor
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameBarros
person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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