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Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale Applications

2024Journal article Open access
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dc.contributor.authorSouza, Andrews
dc.contributor.authorNobrega, Glauco
dc.contributor.authorNeves, Lucas Boniatti
dc.contributor.authorBarbosa, Filipe
dc.contributor.authorRibeiro, J.E.
dc.contributor.authorFerrera, Conrado
dc.contributor.authorLima, Rui A.
dc.date.accessioned2024-12-20T16:31:41Z
dc.date.available2024-12-20T16:31:41Z
dc.date.issued2024
dc.description.abstractPolydimethylsiloxane (PDMS) has become a popular material in microfluidic and macroscale in vitro models due to its elastomeric properties and versatility. PDMS-based biomodels are widely used in blood flow studies, offering a platform for improving flow models and validating numerical simulations. This review highlights recent advances in bioflow studies conducted using both PDMS microfluidic devices and macroscale biomodels, particularly in replicating physiological environments. PDMS microchannels are used in studies of blood cell deformation under confined conditions, demonstrating the potential to distinguish between healthy and diseased cells. PDMS also plays a critical role in fabricating arterial models from real medical images, including pathological conditions such as aneurysms. Cutting-edge applications, such as nanofluid hemodynamic studies and nanoparticle drug delivery in organ-on-a-chip platforms, represent the latest developments in PDMS research. In addition to these applications, this review critically discusses PDMS properties, fabrication methods, and its expanding role in micro- and nanoscale flow studies.pt_PT
dc.description.sponsorshipC. Ferrera gratefully acknowledges funding from the Junta de Extremadura through grant IB20105 (partially funded by FEDER). The authors additionally acknowledge the projects 2022.02085.PTDC (https://doi.org/10.54499/2022.02085.PTDC), 2022.06207.PTDC (https://doi.org/ 10.54499/2022.06207.PTDC), and PTDC/EEI-EEE/2846/2021 (https://doi.org/10.54499/PTDC/EEI-EEE/2846/2021) for the financial support, through national funds (OE), within the scope of the Scientific Research and Technological Development Projects (IC&DT) program in all scientific domains (PTDC), PORTUGAL 2020 Partnership Agreement, European Regional Development Fund (FEDER), via the Foundation for Science and Technology, I.P. (FCT, I.P) and the R&D Units projects UIDB/00690/2020, UIDB/04077/2020, UIDB/04436/2020, UIDB/00532/2020, and SusTEC (LA/P/0007/2020). Andrews Souza acknowledges FCT for the Ph.D. scholarship 2021.07961.BD. Glauco Nobrega was supported by the doctoral grant PRT/BD/153088/2021, financed by the Portuguese Foundation for Science and Technology (FCT), and with funds from MCTES/República Portuguesa, under the MIT Portugal Program).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSouza, Andrews; Nobrega, Glauco; Neves, Lucas B.; Barbosa, Filipe; Ribeiro, João; Ferrera, Conrado; Lima, Rui A. (2024). Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale Applications. Micromachines. ISSN 2072-666X. 15:11, p. 1-22pt_PT
dc.identifier.doi10.3390/mi15111317pt_PT
dc.identifier.issn2072-666X
dc.identifier.urihttp://hdl.handle.net/10198/30773
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPortable Microfluidic system for fast molecular diagnostics of Stroke
dc.relationMultiplexed micro(bio)sensors array integrated into an organ-on-a-chip device for assessing cancer NANOtherapy
dc.relationMountain Research Center
dc.relationMechanical Engineering and Resource Sustainability Center
dc.relationMicroelectromechanical Systems Research Unit
dc.relationTransport Phenomena Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolydimethylsiloxanept_PT
dc.subjectPDMS applicationspt_PT
dc.subjectIn vitro biomodelspt_PT
dc.subjectMicrofluidicspt_PT
dc.subjectBlood flowpt_PT
dc.subjectBiomedical engineeringpt_PT
dc.titleRecent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale Applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortable Microfluidic system for fast molecular diagnostics of Stroke
oaire.awardTitleMultiplexed micro(bio)sensors array integrated into an organ-on-a-chip device for assessing cancer NANOtherapy
oaire.awardTitleMountain Research Center
oaire.awardTitleMechanical Engineering and Resource Sustainability Center
oaire.awardTitleMicroelectromechanical Systems Research Unit
oaire.awardTitleTransport Phenomena Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.02085.PTDC/PT
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oaire.citation.endPage22pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMicromachinespt_PT
oaire.citation.volume15pt_PT
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
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