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Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation

2024Journal article Open access
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dc.contributor.authorPinto, Maria Beatriz
dc.contributor.authorPires, Patrícia C.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorSousa, Maria João
dc.contributor.authorVilas-Boas, Miguel
dc.contributor.authorFalcão, Soraia
dc.contributor.authorVeiga, Francisco
dc.contributor.authorMakvandi, Pooyan
dc.contributor.authorPaiva-Santos, Ana Cláudia
dc.date.accessioned2024-06-27T13:33:07Z
dc.date.available2024-06-27T13:33:07Z
dc.date.issued2024
dc.description.abstractDespite past efforts towards therapeutical innovation, cancer remains a highly incident and lethal disease, with current treatments lacking efficiency and leading to severe side effects. Hence, it is imperative to develop new, more efficient, and safer therapies. Bee venom has proven to have multiple and synergistic bioactivities, including antitumor effects. Nevertheless, some toxic effects have been associated with its administration. To tackle these issues, in this work, bee venom-loaded niosomes were developed, for cancer treatment. The vesicles had a small (150 nm) and homogeneous (polydispersity index of 0.162) particle size, and revealed good therapeutic efficacy in in vitro gastric, colorectal, breast, lung, and cervical cancer models (inhibitory concentrations between 12.37 ng/mL and 14.72 ng/mL). Additionally, they also revealed substantial anti-inflammatory activity (inhibitory concentration of 28.98 ng/mL), effects complementary to direct antitumor activity. Niosome safety was also assessed, both in vitro (skin, liver, and kidney cells) and ex vivo (hen’s egg chorioallantoic membrane), and results showed that compound encapsulation increased its safety. Hence, small, and homogeneous bee venom-loaded niosomes were successfully developed, with substantial anticancer and anti-inflammatory effects, making them potentially promising primary or adjuvant cancer therapies. Future research should focus on evaluating the potential of the developed platform in in vivo models.pt_PT
dc.description.sponsorshipThe present study was supported by the Research and Development Project grant 2022. 05270.PTDC, national funds FCT/MCTES (PIDDAC), CIMO funds (UIDB/00690/2020 and UIDP/ 00690/2020) and SusTEC funds (LA/P/0007/2021), supported by Fundação para a Ciência e a Tecnologia I.P. (FCT, Portugal). The authors are also grateful to Fundação para a Ciência e a Tecnologia I.P. (FCT, Portugal) for contracts’ financial support through the institutional scientific employment program-contract for Soraia I. Falcão and Ricardo C. Calhelha.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPinto, Maria Beatriz; Pires, Patrícia C.; Calhelha, Ricardo C.; Silva, Ana Rita; Sousa, Maria João; Vilas-Boas, Miguel; Falcão, Soraia; Veiga, Francisco; Makvandi, Pooyan; Paiva-Santos, Ana Cláudia (2024). Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation. Pharmaceuticals. ISSN 1424-8247. 17:5, p. 1-24pt_PT
dc.identifier.doi10.3390/ph17050572pt_PT
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10198/29956
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectAnticancerpt_PT
dc.subjectAntitumorpt_PT
dc.subjectBee venompt_PT
dc.subjectIn vitropt_PT
dc.subjectNanosystemspt_PT
dc.subjectNatural compoundspt_PT
dc.subjectNiosomespt_PT
dc.titleBee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.05270.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.citation.endPage24pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume17pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCalhelha
person.familyNameSilva
person.familyNameSousa
person.familyNameVilas-Boas
person.familyNameFalcão
person.givenNameRicardo C.
person.givenNameAna Rita
person.givenNameMaria João
person.givenNameMiguel
person.givenNameSoraia
person.identifierABD-5857-2020
person.identifier1693134
person.identifier711432
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id0E1A-35C1-C79A
person.identifier.ciencia-idD91E-3571-3979
person.identifier.ciencia-idA918-C6FF-81A4
person.identifier.ciencia-idD41A-6BED-4CBB
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5819-9065
person.identifier.orcid0000-0002-9946-4926
person.identifier.orcid0000-0002-8665-5280
person.identifier.orcid0000-0003-3735-6951
person.identifier.ridJ-2172-2014
person.identifier.ridI-5949-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id55230282700
person.identifier.scopus-author-id6602648497
person.identifier.scopus-author-id14832459200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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