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Dietary supplementation with chestnut (Castanea sativa) reduces abdominal adiposity in FVB/n mice: a preliminary study

2020Journal article Open access
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dc.contributor.authorRodrigues, Pedro M.
dc.contributor.authorFerreira, Tiago
dc.contributor.authorNascimento-Gonçalves, Elisabete
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorCosta, Rui Miguel Gil
dc.contributor.authorMartins, Tânia
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorPires, Maria João
dc.contributor.authorLanzarin, Germano
dc.contributor.authorFélix, Luís
dc.contributor.authorVenâncio, Carlos
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBastos, Margarida M.S.M.
dc.contributor.authorMedeiros, Rui
dc.contributor.authorGaivão, Isabel
dc.contributor.authorRosa, Eduardo
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-06-22T10:18:35Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-06-22T10:18:35Z
dc.date.issued2020
dc.description.abstractThe production of chestnut (Castanea sativa Miller) is mostly concentrated in Europe. Chestnut is recognized by its high content of antioxidants and phytosterols. This work aimed to evaluate the e ects of dietary chestnut consumption over physiological variables of FVB/n mice. Eighteen FVB/n male 7-month-old mice were randomly divided into three experimental groups (n = 6): 1 (control group) fed a standard diet; 2 fed a diet supplemented with 0.55% (w/w) chestnut; and 3 supplemented with 1.1% (w/w) chestnut. Body weight, water, and food intake were recorded weekly. Following 35 days of supplementation, the mice were sacrificed for the collection of biological samples. Chestnut supplementation at 1.1% reduced abdominal adipose tissue. Lower serum cholesterol was also observed in animals supplemented with chestnut. There were no significant di erences concerning the incidence of histological lesions nor in biochemical markers of hepatic damage and oxidative stress. These results suggest that chestnut supplementation may contribute to regulate adipose tissue deposition.
dc.description.sponsorshipThis work is supported by National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UIDB/04033/2020, CIMO (UIDB/00690/2020) and UIDB/CVT/00772/2020 Interreg Program for the financial support of the Project IBERPHENOL, Project Number 0377_IBERPHENOL_6_E; co-financed by European Regional Development Fund (ERDF) through POCTEP 2014-2020. This work was also supported by VALORIZEBYPRODUCTS Project, reference n.º 029152, funded by Portuguese Foundation for Science and Technology (FCT) and co-financed by the European Regional Development Fund (FEDER) through COMPETE 2020 - Operational Competitiveness and Internationalization Programme (POCI). This work was also financially supported by Project UID/EQU/00511/2019 - Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE funded by national funds through FCT/MCTES (PIDDAC) and Project “LEPABE-2-ECO-INNOVATION” – NORTE-01-0145-FEDER-000005, funded by Norte Portugal Regional Operational Programme (NORTE 2020), under PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), by the Research Centre of the Portuguese Institute of Oncology of Porto (CI-IPOP 37-2016) and by the Interact R&D project, operation number NORTE-01-0145-FEDER-000017, in its ISAC research line, co-financed by the ERDF through NORTE 2020. This work was also supported by PhD fellowship SFRH/BD/136747/2018.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationRodrigues, Pedro; Ferreira, Tiago; Nascimento-Gonçalves, Elisabete; Seixas, Fernanda; da Costa, Rui Miguel Gil; Martins, Tânia; Neuparth, Maria João; Pires, Maria João; Lanzarin, Germano; Félix, Luís; Venâncio, Carlos; Ferreira, Isabel C.F.R.; Bastos, Margarida M.S.M.; Medeiros, Rui; Gaivão, Isabel; Rosa, Eduardo; Oliveira, Paula A. (2020). Dietary supplementation with chestnut (Castanea sativa) reduces abdominal adiposity in FVB/n mice: a preliminary study. Biomedicines. ISSN 2227-9059. 8:4, p. 1-11en_EN
dc.identifier.doi10.3390/biomedicines8040075en_EN
dc.identifier.urihttp://hdl.handle.net/10198/22316
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAdipose tissueen_EN
dc.subjectCholesterolen_EN
dc.subjectIn vivoen_EN
dc.subjectOxidative stressen_EN
dc.titleDietary supplementation with chestnut (Castanea sativa) reduces abdominal adiposity in FVB/n mice: a preliminary studyen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameRodrigues
person.familyNameFerreira
person.givenNamePedro M.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idC919-D413-5E83
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0009-0002-4920-7398
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id56108282100
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication55f77b39-347e-4ad5-97c6-def43d656014
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8

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