Orientador(es)
Resumo(s)
The production of chestnut (Castanea sativa Miller) is mostly concentrated in Europe.
Chestnut is recognized by its high content of antioxidants and phytosterols. This work aimed to
evaluate the e ects of dietary chestnut consumption over physiological variables of FVB/n mice.
Eighteen FVB/n male 7-month-old mice were randomly divided into three experimental groups
(n = 6): 1 (control group) fed a standard diet; 2 fed a diet supplemented with 0.55% (w/w) chestnut;
and 3 supplemented with 1.1% (w/w) chestnut. Body weight, water, and food intake were recorded
weekly. Following 35 days of supplementation, the mice were sacrificed for the collection of biological
samples. Chestnut supplementation at 1.1% reduced abdominal adipose tissue. Lower serum
cholesterol was also observed in animals supplemented with chestnut. There were no significant di erences concerning the incidence of histological lesions nor in biochemical markers of hepatic
damage and oxidative stress. These results suggest that chestnut supplementation may contribute to
regulate adipose tissue deposition.
Descrição
Palavras-chave
Adipose tissue Cholesterol In vivo Oxidative stress
Contexto Educativo
Citação
Rodrigues, Pedro; Ferreira, Tiago; Nascimento-Gonçalves, Elisabete; Seixas, Fernanda; da Costa, Rui Miguel Gil; Martins, Tânia; Neuparth, Maria João; Pires, Maria João; Lanzarin, Germano; Félix, Luís; Venâncio, Carlos; Ferreira, Isabel C.F.R.; Bastos, Margarida M.S.M.; Medeiros, Rui; Gaivão, Isabel; Rosa, Eduardo; Oliveira, Paula A. (2020). Dietary supplementation with chestnut (Castanea sativa) reduces abdominal adiposity in FVB/n mice: a preliminary study. Biomedicines. ISSN 2227-9059. 8:4, p. 1-11