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Effects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic acid

2019Journal article Open access
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dc.contributor.authorGonçalves, Geferson A.
dc.contributor.authorCorrêa, Rúbia C.G.
dc.contributor.authorBarros, Lillian
dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCorrêa, Vanesa G.
dc.contributor.authorBracht, Adelar
dc.contributor.authorPeralta, Rosane M.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2019-01-28T11:57:40Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2019-01-28T11:57:40Z
dc.date.issued2019
dc.description.abstractThe potential phytochemical losses occurring throughout the sequential steps of in-vitro gastrointestinal digestion and colonic fermentation of a rosemary aqueous extract were investigated. Crude (CE), digested (DE) and fermented (FE) extracts were characterized in terms of their phenolic profile and biological activities. Rosmarinic acid was the phytochemical that underwent the most significate transformation during digestion and fermentation, which amounted to 60% compared to the 26% degradation of the total phenolics. Overall, the simulated digestion step decreased the antioxidant activity estimated by DPPH, ABTS, FRAP, ORAC and TBARS assays. Both CE and DE did not present antiproliferative potential, however, FE exhibited a pronounced cytotoxic activity (GI50 = 116 µg/mL) against HeLa cells. CE and DE showed to be moderate inhibitors of methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible S. aureus (MSSA), S. aureus, Listeria monocytogenes, whilst the FE acted as a moderate inhibitor of MRSA and MSSA.
dc.description.sponsorshipG.A. Gonçalves and V.G. Correa thank Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for the financial support provided for their post-graduate studies in the State University of Maringá. R.C.G. Corrêa thanks Conselho Nacional de Desenvolvimento Científico e Tecnologia ( CNPq ) for financing her postdoctoral research at State University of Maringá (Process number 167378/2017-1). R.M. Peralta (Project number 307944/2015-8) and A. Bracht (Project number 304090/2016-6) are CNPq research grant recipients. The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013), L. Barros and R. Calhelha contracts; and also thank to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E. Appendix A
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGonçalves, Geferson Almeida; Corrêa, Rúbia C.G.; Barros, Lillian; Dias, Maria Inês; Calhelha, Ricardo C.; Corrêa, Vanesa Gesser; Bracht, Adelar; Peralta, Rosane M.; Ferreira, Isabel C.F.R. (2019). Effects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic acid. Food Chemistry. ISSN 0308-8146. 271, p. 393-400en_EN
dc.identifier.doi10.1016/j.foodchem.2018.07.132en_EN
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10198/18359
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAntioxidant activityen_EN
dc.subjectAntiproliferative potentialen_EN
dc.subjectBactericidal effecten_EN
dc.subjectPhytochemicals stabilityen_EN
dc.subjectRosmarinic acid-enriched extractsen_EN
dc.titleEffects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic aciden_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.fundingStream5876
person.familyNameCorrêa
person.familyNameBarros
person.familyNameDias
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRúbia C.G.
person.givenNameLillian
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier469085
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person.identifier.orcid0000-0003-0269-4344
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridM-8242-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id37661286600
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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