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Phenolic plant extracts versus penicillin G: In vitro susceptibility of Staphylococcus aureus isolated from bovine mastitis

2019Journal article Open access
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dc.contributor.authorGomes, Fernanda
dc.contributor.authorRodrigues, Maria Elisa
dc.contributor.authorMartins, Natália
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorHenriques, Mariana
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-06T14:10:05Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-06T14:10:05Z
dc.date.issued2019
dc.description.abstractAntibiotics are the elective drugs in bovine mastitis (BM) treatment, despite their low rates of e ciency and e ectiveness and increasing risk of pathogen resistance. In this sense, it is urgent to discover new and e ective antimicrobial agents to apply in BM control and even treatment. Plant extracts have been widely recognized as a rich source of phytochemicals with antimicrobial potential. Thus, the present work aims to compare the bioactivity of Eucalyptus globulus and Juglans regia extracts against Staphylococcus aureus bovine mastitis strains with penicillin G. At non-toxic concentrations, E. globulus exerted a bacteriostatic e ect in planktonic cells and J. regia had no antimicrobial activity. Penicillin G, at minimum inhibitory concentration (MIC), demonstrated bactericidal activity, but just for S. aureus 3, 5, 6 and ATCC 25923, while the other strains seem to have acquired resistance. On the other hand, E. globulus and penicillin G in combination demonstrated synergy, being the most e ective approach against S. aureus 1, 2 and 4. Thus, penicillin alone and in combination with E. globulus or J. regia seems to be promissory strategies to control bovine mastitis infections.
dc.description.sponsorshipThis study was supported by the Portuguese Foundation for Science and Technology (FCT) (grants number SFRH/BPD/84488/2012 and SFRH/BPD/95401/2013) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by European Regional Development Fund under the scope of the Norte2020 Programa Operacional Regional do Norte, as also Pest-OE/AGR/UI0690/2014 to CIMO. The authors also acknowledge Ana Maria Carvalho for the collection and identification of the wild samples, chemically characterized in previous studies. N. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT–Portugal) for the Strategic project ref. UID/BIM
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGomes, Fernanda; Rodrigues, Maria Elisa; Martins, Natália; Ferreira, Isabel C.F.R.; Henriques, Mariana (2019). Phenolic plant extracts versus penicillin G: In vitro susceptibility of Staphylococcus aureus isolated from bovine mastitis. Pharmaceuticals. ISSN 1424-8247. 12, p. 1-8en_EN
dc.identifier.doi10.3390/ph12030128en_EN
dc.identifier.urihttp://hdl.handle.net/10198/20261
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationNEW NATURAL ANTIMICROBIAL AGENTS FROM OLEA EUROPAEA L. IN DAIRY INDUSTRY PATHOGENS CONTROL
dc.relationNOVEL STRATEGIES TO FIGHT CANDIDA SPECIES INFECTION
dc.subjectBovine mastitisen_EN
dc.subjectEucalyptus globulus Labillen_EN
dc.subjectJuglans regia L.en_EN
dc.subjectPenicillin Gen_EN
dc.subjectStaphylococcus aureusen_EN
dc.titlePhenolic plant extracts versus penicillin G: In vitro susceptibility of Staphylococcus aureus isolated from bovine mastitisen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNEW NATURAL ANTIMICROBIAL AGENTS FROM OLEA EUROPAEA L. IN DAIRY INDUSTRY PATHOGENS CONTROL
oaire.awardTitleNOVEL STRATEGIES TO FIGHT CANDIDA SPECIES INFECTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F84488%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F95401%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIO%2F04469%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameFerreira
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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