Publication
Axisymmetric PDMS (polydimethysiloxane) microchannels for in vitro haemodynamic studies
| dc.contributor.author | Lima, Rui A. | |
| dc.contributor.author | Oliveira, Mónica S.N. | |
| dc.contributor.author | Ishikawa, Takuji | |
| dc.contributor.author | Kaji, Hirokazu | |
| dc.contributor.author | Tanaka, Shuji | |
| dc.contributor.author | Nishizawa, Matsuhiko | |
| dc.contributor.author | Yamaguchi, Takami | |
| dc.date.accessioned | 2010-01-31T13:25:35Z | |
| dc.date.available | 2010-01-31T13:25:35Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | The current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular PDMS microchannels aiming to mimic in vivo microvascular environment and suitable for state-of-the-art microscale flow visualization techniques, such as confocal uPIV/PTV. By using a confocal uPTV system individual red blood cells (RBCs) were successfully tracked trough a 75 um circular PDMS microchannel. The results show that RBC lateral dispersion increases with the volume fraction of RBCs in the solution, i.e. with the hematocrit. | pt |
| dc.description.sponsorship | This study was supported in part by the following grants: International Doctoral Program in Engineering from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) and Grant-in-Aid for Scientific Research (S) from the Japan Society for the Promotion of Science (JSPS; No.19100008). We also acknowledge the support from the 2007 Global COE Program “Global Nano-Biomedical Engineering Educationand Research Network. The authors would like also to thank Dr. Motohiro Takeda from Tohoku University for providing the blood samples and Dr. Paulo André for supplying some of the optical fibers tested in this work. | |
| dc.identifier.citation | Lima, R.; Oliveira, M. S. N.; Ishikawa, T.; Kaji, H.; Tanaka, S.; Nishizawa, M.; Yamaguchi, T. (2009). Axisymmetric PDMS microchannels for in vitro haemodynamic studies. Biofabrication. ISSN 1758-5082. 1:3 | pt |
| dc.identifier.issn | 1758-5090 | |
| dc.identifier.uri | http://hdl.handle.net/10198/1605 | |
| dc.language.iso | eng | pt |
| dc.publisher | IOP | pt |
| dc.subject | Axisymmetric PDMS microchannel | pt |
| dc.subject | Microcirculation | pt |
| dc.subject | Red blood cells | pt |
| dc.subject | Confocal micro-PTV | pt |
| dc.title | Axisymmetric PDMS (polydimethysiloxane) microchannels for in vitro haemodynamic studies | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Biofabrication | pt |
| person.familyName | Lima | |
| person.givenName | Rui A. | |
| person.identifier.ciencia-id | EE12-C3FB-349D | |
| person.identifier.orcid | 0000-0003-3428-637X | |
| person.identifier.rid | H-5157-2016 | |
| person.identifier.scopus-author-id | 18437397800 | |
| rcaap.rights | openAccess | pt |
| rcaap.type | article | pt |
| relation.isAuthorOfPublication | 7b50c499-8095-4f4f-8b1b-fa7388e4ff62 | |
| relation.isAuthorOfPublication.latestForDiscovery | 7b50c499-8095-4f4f-8b1b-fa7388e4ff62 |