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Advisor(s)
Abstract(s)
The current microdevices used for biomedical research are often manufactured using
microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and
reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may
not reflect the actual physiology of the microcirculation. Here, we present a simple method to
fabricate circular PDMS microchannels aiming to mimic in vivo microvascular environment and
suitable for state-of-the-art microscale flow visualization techniques, such as confocal uPIV/PTV. By
using a confocal uPTV system individual red blood cells (RBCs) were successfully tracked trough a
75 um circular PDMS microchannel. The results show that RBC lateral dispersion increases with the
volume fraction of RBCs in the solution, i.e. with the hematocrit.
Description
Keywords
Axisymmetric PDMS microchannel Microcirculation Red blood cells Confocal micro-PTV
Citation
Lima, R.; Oliveira, M. S. N.; Ishikawa, T.; Kaji, H.; Tanaka, S.; Nishizawa, M.; Yamaguchi, T. (2009). Axisymmetric PDMS microchannels for in vitro haemodynamic studies. Biofabrication. ISSN 1758-5082. 1:3