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Motion of rigid particles flowing in a microfluidic device with a pronounced stenosis: trajectories and deformation index

2014Conference object Open access
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dc.contributor.authorPinho, Diana
dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorYaginuma, Tomoko
dc.contributor.authorFaustino, Vera
dc.contributor.authorBento, David
dc.contributor.authorFernandes, Carla S.
dc.contributor.authorGarcia, Valdemar
dc.contributor.authorPereira, Ana I.
dc.contributor.authorLima, Rui A.
dc.date.accessioned2015-12-15T10:55:49Z
dc.date.available2015-12-15T10:55:49Z
dc.date.issued2014
dc.description.abstractStudies of in vitro blood flow behaviour in stenosis are essential not only as an attempt to understand this phenomenon, but also to develop microfluidic devices, as an alternative clinical methodology to detect blood diseases. Regarding a better understanding of the role that rigid Red Blood Cells (rRBCs) play in the blood flow behaviour, we have studied the trajectories and deformation of both, artificial rigid Red Blood Cells (arRBCs) and healthy ovine Red Blood Cells (RBCs), when subjected to a pronounced microstenosis. By using a high-speed video microscopy system, the present study was performed with different flow rates (1, 10 and 20 µl/min). The results have shown that healthy RBCs and arRBCs present deviations in their flow behaviour and deformation index, which might be a potential alternative clinical methodology to detect blood cells related diseases.pt_PT
dc.description.sponsorshipThe authors acknowledge the financial support provided by PTDC/SAU-BEB/105650/2008, PTDC/EME-MFE/099109/2008, PTDC/SAU-ENB/116929/2010, EXPL/EMS-SIS/2215/2013, scholarship SFRH/BD/91192/2012 and scholarship SFRH/BD/89077/2012 from FCT (Science and Technology Foundation), COMPETE, QREN and European Union (FEDER).
dc.identifier.citationPinho, Diana; Rodrigues, Raquel O.; Yaginuma, T.; Faustino, Vera; Bento, David; Fernandes, Carla S.; Garcia, Valdemar; Pereira, Ana I.; Lima, R. (2014). Motion of rigid particles flowing in a microfluidic device with a pronounced stenosis: trajectories and deformation index. In 11th World Congress on Computational Mechanics, 5th European Conference on Computational Mechanics and 6th European Conference on Computational Fluid Dynamics, IACM-ECOMAS2014. Barcelona, Spain. p. 6234-6240pt_PT
dc.identifier.isbn978-84-942844-7-2
dc.identifier.urihttp://hdl.handle.net/10198/12524
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.relationMicroBloodSystems - Blood rheology and blood cell migration in microfluidic systems
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRigid particlespt_PT
dc.subjectRed blood cellspt_PT
dc.subjectMicrochannel with stenosispt_PT
dc.subjectTrajectoriespt_PT
dc.subjectDeformation indexpt_PT
dc.titleMotion of rigid particles flowing in a microfluidic device with a pronounced stenosis: trajectories and deformation indexpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardTitleMicroBloodSystems - Blood rheology and blood cell migration in microfluidic systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/EXPL%2FEMS-SIS%2F2215%2F2013/PT
oaire.citation.conferencePlaceBarcelona, Sapinpt_PT
oaire.citation.endPage6240pt_PT
oaire.citation.startPage6234pt_PT
oaire.citation.title11th World Congress on Computational Mechanics, 5th European Conference on Computational Mechanics and 6th European Conference on Computational Fluid Dynamicspt_PT
oaire.fundingStream5876-PPCDTI
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oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNamePinho
person.familyNameFernandes
person.familyNameGarcia
person.familyNamePereira
person.familyNameLima
person.givenNameDiana
person.givenNameCarla S.
person.givenNameValdemar
person.givenNameAna I.
person.givenNameRui A.
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person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0002-3138-7493
person.identifier.orcid0000-0002-3941-2438
person.identifier.orcid0000-0003-3803-2043
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridA-4269-2015
person.identifier.ridF-3168-2010
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id8253740700
person.identifier.scopus-author-id15071961600
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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