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Nanoencapsulation of Curcuma longa L. extract for the treatment of experimental colitis

2023Journal article Restricted access
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dc.contributor.authorLuz, Débora dos Anjos Weber
dc.contributor.authorRampazzo, Ana Paula de Santi
dc.contributor.authorBorges, Stephanie Carvalho
dc.contributor.authorNeves, Camila Quaglio
dc.contributor.authorSantos, Priscila Dayane Freitas dos
dc.contributor.authorButtow, Nilza Cristina
dc.contributor.authorPires, Cassiano
dc.contributor.authorFreitas, Rilton Alves de
dc.contributor.authorAmado, Ciomar Aparecida Bersani
dc.contributor.authorGonçalves, Odinei Hess
dc.contributor.authorNatali, Maria Raquel Marçal
dc.date.accessioned2023-12-19T09:59:07Z
dc.date.available2023-12-19T09:59:07Z
dc.date.issued2023
dc.description.abstractInflammatory bowel diseases (IBDs) are gastrointestinal chronic inflammatory diseases characterized by chronic and recurrent intestinal ulcerations. Curcuminoids are naturally occurring polyphenolic compounds with remarkable bioactivity; however, their low water affinity and bioavailability usually hinder their application. Encapsulation techniques can be coupled with extraction procedures to yield nanoparticles that may have enhanced properties. In this work, curcuminoids were extracted from rhizomes of Curcuma longa L. and simultaneously encapsulated using ultrasound. The characterization of the curcuminoids nanoparticles showed that particles ranging from 124 ± 81 to 252 ± 68 nm were formed, and the main properties of the curcuminoids were maintained after encapsulation. Experimental colitis was induced in rats by 2,4,6-trinitrobenzene sulfonic acid, and they were subsequently treated with 10, 25, or 50 mg kg-1 of nanoencapsulated curcuminoids for 7 days through gavage, during which the disease activity index (DAI) was evaluated. Then the rats were euthanized, and the distal colon was removed for macroscopic analysis and the assessment of the activity of the enzymes myeloperoxidase and N-acetylglucosaminidase. The dose of 25 mg kg-1 of nanoencapsulated curcuminoids reduced the DAI and the activity of inflammatory enzymes compared to the untreated group and was established as the minimum effective dose to be used in the treatment of this model of experimental colitis in rats.pt_PT
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel - CAPES (001) and the Araucária Foundation for Scientific and Technological Development of the State of Paraná (472223).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLuz, Débora dos Anjos Weber; Rampazzo, Ana Paula de Santi; Borges, Stephanie Carvalho; Neves, Camila Quaglio; Santos, Priscila Dayane Freitas dos; Buttow, Nilza Cristina; Pires, Cassiano; Freitas, Rilton Alves de; Amado, Ciomar Aparecida Bersani; Gonçalves, Odinei Hess; Natali, Maria Raquel Marçal (2023). Nanoencapsulation of Curcuma longa L. extract for the treatment of experimental colitis. Food Bioscience. ISSN 2212-4292. 55, p. 1-9pt_PT
dc.identifier.doi10.1016/j.fbio.2023.103052pt_PT
dc.identifier.eissn2212-4306
dc.identifier.issn2212-4292
dc.identifier.urihttp://hdl.handle.net/10198/28971
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectNanoparticlespt_PT
dc.subjectCurcuminoidspt_PT
dc.subjectMyeloperoxidasept_PT
dc.subjectN-acetylglucosaminidasept_PT
dc.titleNanoencapsulation of Curcuma longa L. extract for the treatment of experimental colitispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFood Biosciencept_PT
oaire.citation.volume55pt_PT
person.familyNameGonçalves
person.givenNameOdinei Hess
person.identifier.orcid0000-0002-9528-8187
person.identifier.scopus-author-id9335958400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication84c8eea0-77bb-4c18-b9d8-46f865980706
relation.isAuthorOfPublication.latestForDiscovery84c8eea0-77bb-4c18-b9d8-46f865980706

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