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Advisor(s)
Abstract(s)
Inflammatory bowel diseases (IBDs) are gastrointestinal chronic inflammatory diseases characterized by chronic
and recurrent intestinal ulcerations. Curcuminoids are naturally occurring polyphenolic compounds with
remarkable bioactivity; however, their low water affinity and bioavailability usually hinder their application.
Encapsulation techniques can be coupled with extraction procedures to yield nanoparticles that may have
enhanced properties. In this work, curcuminoids were extracted from rhizomes of Curcuma longa L. and simultaneously
encapsulated using ultrasound. The characterization of the curcuminoids nanoparticles showed that
particles ranging from 124 ± 81 to 252 ± 68 nm were formed, and the main properties of the curcuminoids were
maintained after encapsulation. Experimental colitis was induced in rats by 2,4,6-trinitrobenzene sulfonic acid,
and they were subsequently treated with 10, 25, or 50 mg kg-1 of nanoencapsulated curcuminoids for 7 days
through gavage, during which the disease activity index (DAI) was evaluated. Then the rats were euthanized, and
the distal colon was removed for macroscopic analysis and the assessment of the activity of the enzymes myeloperoxidase
and N-acetylglucosaminidase. The dose of 25 mg kg-1 of nanoencapsulated curcuminoids reduced
the DAI and the activity of inflammatory enzymes compared to the untreated group and was established as the
minimum effective dose to be used in the treatment of this model of experimental colitis in rats.
Description
Keywords
Inflammatory bowel disease Nanoparticles Curcuminoids Myeloperoxidase N-acetylglucosaminidase
Pedagogical Context
Citation
Luz, Débora dos Anjos Weber; Rampazzo, Ana Paula de Santi; Borges, Stephanie Carvalho; Neves, Camila Quaglio; Santos, Priscila Dayane Freitas dos; Buttow, Nilza Cristina; Pires, Cassiano; Freitas, Rilton Alves de; Amado, Ciomar Aparecida Bersani; Gonçalves, Odinei Hess; Natali, Maria Raquel Marçal (2023). Nanoencapsulation of Curcuma longa L. extract for the treatment of experimental colitis. Food Bioscience. ISSN 2212-4292. 55, p. 1-9
Publisher
Elsevier