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Formulation and optimization of nanoemulsions using the natural surfactant saponin from Quillaja bark

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dc.contributor.authorSchreiner, Tatiana B.
dc.contributor.authorSantamaria-Echart, Arantzazu
dc.contributor.authorRibeiro, Andreia
dc.contributor.authorPeres, António M.
dc.contributor.authorDias, Madalena M.
dc.contributor.authorPinho, Simão
dc.contributor.authorBarreiro, M.F.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-06-22T10:18:49Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-06-22T10:18:49Z
dc.date.issued2020
dc.description.abstractReplacing synthetic surfactants by natural alternatives when formulating nanoemulsions has gained attention as a sustainable approach. In this context, nanoemulsions based on sweet almond oil and stabilized by saponin from Quillaja bark with glycerol as cosurfactant were prepared by the high-pressure homogenization method. The e ects of oil/water (O/W) ratio, total surfactant amount, and saponin/glycerol ratio on their stability were analyzed. The formation and stabilization of the oil-in-water nanoemulsions were analyzed through the evaluation of stability over time, pH, zeta potential, and particle size distribution analysis. Moreover, a design of experiments was performed to assess the most suitable composition based on particle size and stability parameters. The prepared nanoemulsions are, in general, highly stable over time, showing zeta potential values lower than 􀀀40 mV, a slight acid behavior due to the character of the components, and particle size (in volume) in the range of 1.1 to 4.3 m. Response surface methodology revealed that formulations using an O/W ratio of 10/90 and 1.5 wt% surfactant resulted in lower particle sizes and zeta potential, presenting higher stability. The use of glycerol did not positively a ect the formulations, which reinforces the suitability of preparing highly stable nanoemulsions based on natural surfactants such as saponins.
dc.description.sponsorshipThis research was funded by (1) AIProcMat@N2020-Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020, with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); (2) Base Funding—UIDB/50020/2020 of the Associate Laboratory LSRE-LCM—funded by national funds through FCT/MCTES (PIDDAC); and (3) Base Funding—(UIDB/00690/2020) of CIMO—Centro de Investigação de Montanha—funded by national funds through FCT/MCTES (PIDDAC).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSchreiner, Tatiana B.; Santamaria-Echart, Arantzazu; Ribeiro, Andreia; Peres, António M.; Dias, Madalena M.; Pinho, Simão P.; Barreiro, Maria Filomena (2020). Formulation and optimization of nanoemulsions using the natural surfactant saponin from Quillaja bark. Molecules. ISSN 1420-3049. 25:7, p. 1-14en_EN
dc.identifier.doi10.3390/molecules25071538en_EN
dc.identifier.urihttp://hdl.handle.net/10198/22339
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.subjectDesign of experimentsen_EN
dc.subjectHigh-pressure homogenizationen_EN
dc.subjectNanoemulsionsen_EN
dc.subjectParticle size distributionen_EN
dc.subjectQuillaja bark saponinen_EN
dc.subjectZeta potentialen_EN
dc.titleFormulation and optimization of nanoemulsions using the natural surfactant saponin from Quillaja barken_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00690/2020
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSchreiner
person.familyNameSantamaria-Echart
person.familyNamePeres
person.familyNamePinho
person.familyNameBarreiro
person.givenNameTatiana B.
person.givenNameArantzazu
person.givenNameAntónio M.
person.givenNameSimão
person.givenNameFilomena
person.identifier107333
person.identifier810882
person.identifier.ciencia-idBA13-066A-678F
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person.identifier.ciencia-id481D-73AD-8D0F
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0001-8436-9216
person.identifier.orcid0000-0003-0107-7301
person.identifier.orcid0000-0001-6595-9165
person.identifier.orcid0000-0002-9211-857X
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridI-8470-2012
person.identifier.ridD-4148-2013
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id56725697700
person.identifier.scopus-author-id7102331969
person.identifier.scopus-author-id7003570175
person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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