Orientador(es)
Resumo(s)
Replacing synthetic surfactants by natural alternatives when formulating nanoemulsions
has gained attention as a sustainable approach. In this context, nanoemulsions based on sweet
almond oil and stabilized by saponin from Quillaja bark with glycerol as cosurfactant were prepared
by the high-pressure homogenization method. The e ects of oil/water (O/W) ratio, total surfactant
amount, and saponin/glycerol ratio on their stability were analyzed. The formation and stabilization
of the oil-in-water nanoemulsions were analyzed through the evaluation of stability over time,
pH, zeta potential, and particle size distribution analysis. Moreover, a design of experiments was
performed to assess the most suitable composition based on particle size and stability parameters.
The prepared nanoemulsions are, in general, highly stable over time, showing zeta potential values
lower than 40 mV, a slight acid behavior due to the character of the components, and particle size
(in volume) in the range of 1.1 to 4.3 m. Response surface methodology revealed that formulations
using an O/W ratio of 10/90 and 1.5 wt% surfactant resulted in lower particle sizes and zeta
potential, presenting higher stability. The use of glycerol did not positively a ect the formulations,
which reinforces the suitability of preparing highly stable nanoemulsions based on natural surfactants
such as saponins.
Descrição
Palavras-chave
Design of experiments High-pressure homogenization Nanoemulsions Particle size distribution Quillaja bark saponin Zeta potential
Contexto Educativo
Citação
Schreiner, Tatiana B.; Santamaria-Echart, Arantzazu; Ribeiro, Andreia; Peres, António M.; Dias, Madalena M.; Pinho, Simão P.; Barreiro, Maria Filomena (2020). Formulation and optimization of nanoemulsions using the natural surfactant saponin from Quillaja bark. Molecules. ISSN 1420-3049. 25:7, p. 1-14