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Advisor(s)
Abstract(s)
Quinolinones, of which the quinolin-4(1H)-one ring system can be highlighted, represent
an exciting class of nitrogen heterocycles. The quinolinone motif can be found in many
natural compounds and approved drugs for several diseases. This chapter is a comprehensive
survey of the methods for the synthesis of quinolin-2(1H)-ones, quinolin-4(1H)-ones,
and their thio- and amino derivatives, and is an update to the previous Science of Synthesis
chapter (Section 15.4), covering the period between 2003 and 2020.
Description
Keywords
Amides Amines Anilides Annulations Carbon–carbon bonds Carbon– nitrogen bonds Carbonyl compounds Enaminones Heterocycles Lactamization Quinolines Quinolinamines Ring-closing reactions Ring expansion Tandem reactions Palladium catalysts
Pedagogical Context
Citation
Silva, Vera L.M.; Pinto, Diana; Santos, Clementina M.M.; Rocha, Djenisa (2022). Quinolinones and related systems (Update 2022). In Science of Synthesis Knowledge Updates 2022/3. Stuttgart: Georg Thieme Verlag KG, p. 183-442
Publisher
Georg Thieme Verlag