A carregar...
Publicação
Polymeric Modulation of Natural Microcapsules: A Multimodal Platform for Enhanced Mucoadhesion and Site‐Specific Oral Drug Delivery
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.66 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Sporopollenin, a highly robust, biocompatible, and chemically resistant biopolymer derived from pollen grains, represents an underexploited renewable resource for sustainable pharmaceutical applications. Therewith, the broader application of oral pollen-based systems is restricted by morphology-related limitations, premature gastric release, and insufficient intestinal adhesion. Herein, sporopollenin microcapsules (SMCs) were produced from Castanea sp. (Cas) and Helianthus sp. (Hel) bee pollen using a solvent-efficient, scalable purification strategy. The microcapsules were then surface-functionalized via a clean photochemical approach to enhance mucoadhesion and coated with either biodegradable alginate (Alg) or pH-responsive eudragit (Eud), modulating the controlled intestinal release of the model drug 5-Fluorouracil (5-FU). Scanning electron microscope (SEM), confocal laser scanning microscopy (CLSM), and laser diffraction particle analysis confirmed successful purification, with average sizes of 11.2 mu m (Cas) and 24.1 mu m (Hel). Drug loading capacities were 29% and 36%, respectively, and Fourier-transform infrared (FTIR) and thermogravimetric analysis (TGA) validated successful encapsulation. Uncoated SMCs released 63%-73% of 5-FU within 1 h, whereas Alg or Eud coatings delayed release, achieving sustained, super case-II transport profiles. Bioadhesion testing showed Hel-SMCs had a higher work of adhesion (0.298 mJ/cm(2)) than Cas-SMCs (0.079 mJ/cm(2)), supporting prolonged residence in the target site. Biocompatibility assays of SMCs in Vero cells indicated no cytotoxic effects, GI(50) > 700 mu g/mL. Overall, polymer-coated SMCs demonstrate strong potential as sustainable oral drug delivery systems, integrating effective encapsulation, controlled and mucoadhesive release behavior with multifunctional, low-waste design principles that advance sustainable pharmacy and resource efficiency.
Descrição
Palavras-chave
Bee pollen Controlled delivery Mucoadhesion enhancement biocompatibility Polymer coating Sporopollenin-based carriers
Contexto Educativo
Citação
Aylanc, Volkan; Ertosun, Seymanur; Vale, Nuno; Freire, Cristina; Vilas-Boas, Miguel (2026). Polymeric Modulation of Natural Microcapsules: A Multimodal Platform for Enhanced Mucoadhesion and Site-Specific Oral Drug Delivery. Polymers for Advanced Technologies. ISSN 1042-7147. 37:5, p. 1-15
Editora
Wiley