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A green method for anthocyanin extraction from Clitoria ternatea flowers cultivated in southern Brazil: characterization, in vivo toxicity, and biological activity

2024Journal article Restricted access
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dc.contributor.authorGonçalves, Glória C.P.
dc.contributor.authorRosas, Alexandra L.G.
dc.contributor.authorSousa, Rafael C. de
dc.contributor.authorVieira, Thaís R.R.
dc.contributor.authorSousa, Thamyres C. de Albuquerque
dc.contributor.authorRamires, Tassiana
dc.contributor.authorSilveira, Tayse F. F. da
dc.contributor.authorBarros, Lillian
dc.contributor.authorSilva, Wladimir Padilha da
dc.contributor.authorDias, Álvaro R.G.
dc.contributor.authorZavareze, Elessandra da Rosa
dc.contributor.authorMeinhart, Adriana Dillenburg
dc.date.accessioned2024-01-15T11:58:58Z
dc.date.available2024-01-15T11:58:58Z
dc.date.issued2024
dc.description.abstractThis study aimed to develop a green method to obtain an anthocyanin-rich edible extract of Clitoria ternatea flowers grown in southern Brazil. The extract was characterized by UHPLC-MSn and analyzed for toxicological potential in an in vivo model, total phenolic content, and biological activities. By using a 23 multivariate design to study the effects of temperature, acidified solvent, and time on the total anthocyanin content (487.25 mg/g), total phenolic content (2242.47 mgGAE/g), it was possible to determine the optimal point (45 ◦C, 16 min, and 22.5 mL extraction solution). Thirteen anthocyanins and nine non-anthocyanins were quantified. In vivo toxicity assay using Galleria mellonella showed a safe concentration when administered up to 2.2 g of extract per body kg. The extract showed antioxidant activity and antibacterial action against food pathogens, the method proved to have a low environmental impact, in addition to producing an extract with potential for application in food.pt_PT
dc.description.sponsorshipThe authors are grateful for the funding by Coordenaç˜ao de Aperfeiçoamento de Pessoal de Superior - CAPES (Financial Code 001), Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPQ (306378/2015–9), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul - FAPERGS (17/255100009126), the Southern Electronic Microscopy Center (CEME-SUL) of the Federal University of Rio Grande (FURG). The authors are also grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (UIDB/ 00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020) and national funding by FCT, P.I., through the institutional scientific employment program-contract for L. Barros contract. T. Silveira thanks the Fundação BPI La Caixa, within project titled ‘AquaeVitae - Água Termal Como Fonte de Vida e Saúde” - “PROMOVE – O futuro do Interior” call 2020 for her contract. The authors state that there are no conflicts of interest in the study’s publication. The research is registered with the Ministry of the Environment of Brazil, in the National System of Management of Genetic Heritage and Associated Traditional Knowledge, under number A937529. We would also like to thank Atlas Assessoria Linguística for language editing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, Glória C.P.; Rosas, Alexandra L.G.; Sousa, Rafael C. de; Vieira, Thaís R.R.; Sousa, Thamyres C. de Albuquerque; Ramires, Tassiana; Silveira, Tayse Ferreira; Barros, Lillian; Silva, Wladimir Padilha da; Dias, Álvaro R.G.; Zavareze, Elessandra da Rosa; Meinhart, Adriana Dillenburg (2024). A green method for anthocyanin extraction from Clitoria ternatea flowers cultivated in southern Brazil: characterization, in vivo toxicity, and biological activity. Food Chemistry. ISSN 0308-8146. 435, p. 1-9pt_PT
dc.identifier.doi10.1016/j.foodchem.2023.137575pt_PT
dc.identifier.eissn1873-7072
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10198/29186
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnthocyaninspt_PT
dc.subjectPhenolicspt_PT
dc.subjectToxicitypt_PT
dc.subjectClitoria ternateapt_PT
dc.titleA green method for anthocyanin extraction from Clitoria ternatea flowers cultivated in southern Brazil: characterization, in vivo toxicity, and biological activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFood Chemistrypt_PT
oaire.citation.volume435pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilveira
person.familyNameBarros
person.givenNameTayse F. F. da
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id541E-97D4-A3E5
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01
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