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Resistance Training Before Hyperalgesia Induction Promotes Analgesic Effects Through Central and Peripheral Biomarker Modulation in an Experimental Fibromyalgia-like Model

2025Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Sociais::Outras Ciências Sociais
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorChiapeta, Andrês Valente
dc.contributor.authorOliveira, Leandro Licursi
dc.contributor.authorLeite, Luciano Bernardes
dc.contributor.authorSilva, Bruna Aparecida Fonseca da
dc.contributor.authorCosta, Sebastião Felipe Ferreira
dc.contributor.authorSoares, Leôncio Lopes
dc.contributor.authorMoraes, Alexa Alves de
dc.contributor.authorDrummond, Lucas Rios
dc.contributor.authorForte, Pedro
dc.contributor.authorNatali, Antônio José
dc.contributor.authorCarneiro-Júnior, Miguel Araújo
dc.date.accessioned2025-10-10T15:55:55Z
dc.date.available2025-10-10T15:55:55Z
dc.date.issued2025
dc.description.abstractFibromyalgia is a chronic syndrome characterized by widespread pain and complex pathophysiology, requiring new therapeutic approaches. This study aims to investigate the effects of resistance training (RT) before hyperalgesia induction on pain sensitivity, IL-6 and IL-10 expression in skeletal muscle, and thalamic serotonin levels in a fibromyalgia (FM)-like rat model. Methods: Wistar female rats aged 12 months were divided into four groups: untrained neutral saline (UNS), untrained acid saline (UAS), RT neutral saline (RTN), and RT acid saline (RTA). Both the RTN and RTA groups were subjected to an RT protocol comprising vertical ladder climbing three times a week throughout 14 weeks. The UAS and RTA groups received 100 mu L of neutral, sterile saline (pH 4.0) in the left gastrocnemius muscle, while the UNS and RTN groups received 100 mu L of neutral saline (pH 7.4). Mechanical hyperalgesia was assessed using Von Frey's electronic esthesiometer. Expression of interleukins 6 (IL-6) and 10 (IL-10) was analyzed in skeletal muscle, and serotonin expression was quantified in the thalamus. Results: After hyperalgesia induction, the RT groups demonstrated higher paw withdrawal thresholds than the UAS group (p < 0.05). Both IL-6 and IL-10 expression was lower in the RTA group compared to the UAS group (p < 0.05). Thalamic serotonin expression was higher (p < 0.05) in the RTA group compared to the UAS group. Conclusion: Previous RT was able to prevent mechanical hyperalgesia experienced by rats after its induction by acid saline by preventing the increase in the IL-6 and IL-10 levels in skeletal muscle and preventing the decrease in thalamic serotonin expression.eng
dc.description.sponsorshipThis study was financed by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001, the Fundação de Amparo à Pesquisa do Estado de Minas Gerais—Brasil (FAPEMIG) [APQ-03879–23 and APQ-03316–23], the Conselho Nacional de Desenvolvimento Científico e Tecnológico—Brasil (CNPq), and the Universidade do Estado de Minas Gerais (UEMG).
dc.identifier.citationChiapeta, Andrês Valente; Oliveira, Leandro Licursi; Leite, Luciano Bernardes; Silva, Bruna Aparecida Fonseca da; Costa, Sebastião Felipe Ferreira; Soares, Leôncio Lopes; Moraes, Alexa Alves de; Drummond, Lucas Rios; Forte, Pedro; Natali, Antônio José; Carneiro-Júnior, Miguel Araújo (2025). Resistance Training Before Hyperalgesia Induction Promotes Analgesic Effects Through Central and Peripheral Biomarker Modulation in an Experimental Fibromyalgia-like Model. Life. ISSN 2075-1729. 15:6, p. 1-12
dc.identifier.doi10.3390/life15060849
dc.identifier.issn2075-1729
dc.identifier.urihttp://hdl.handle.net/10198/34813
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAPQ-03879–23
dc.relation.ispartofLife
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectPhysical exercise
dc.subjectChronic pain
dc.subjectCytokines
dc.subjectSerotonin
dc.titleResistance Training Before Hyperalgesia Induction Promotes Analgesic Effects Through Central and Peripheral Biomarker Modulation in an Experimental Fibromyalgia-like Modeleng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12
oaire.citation.issue6
oaire.citation.startPage1
oaire.citation.titleLife
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameForte
person.givenNamePedro
person.identifier.ciencia-id351B-B16B-79C7
person.identifier.orcid0000-0003-0184-6780
relation.isAuthorOfPublication3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0
relation.isAuthorOfPublication.latestForDiscovery3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0

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