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Evaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal Plants

2022Journal article Open access
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dc.contributor.authorEssoh, Anyse P.
dc.contributor.authorLiberal, Ângela
dc.contributor.authorFernandes, Ângela
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPereira, Carla
dc.contributor.authorMandim, Filipa
dc.contributor.authorMoldão-Martins, Margarida
dc.contributor.authorCravo, Pedro V.L.
dc.contributor.authorDuarte, Maria Paula
dc.contributor.authorMoura, Monica B.M.V.
dc.contributor.authorRomeiras, Maria M.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2023-08-03T11:04:23Z
dc.date.available2023-08-03T11:04:23Z
dc.date.issued2022
dc.description.abstractThe use of medicinal plants in a variety of health conditions remains essential for the discovery of new treatments. The present study aimed to investigate the bioactive properties of three native plants from Cabo Verde Islands, namely Artemisia gorgonum Webb, Sideroxylon marginatum (Decne. ex Webb) Cout., and Tamarix senegalensis DC., contributing to the characterization of less- known medicinal plants and their potential benefits for human health. Known compounds, such as kaempferol, quercetin, caffeyolquinic, and apigenin derivatives, among others, were detected in the plant species under study. Overall, all species demonstrated good antioxidant capacity, especially the ethanolic extracts of A. gorgonum (EC50 = 0.149 mg/mL) in TBARS assay. Moreover, the ethanolic extracts of the studied plants showed cytotoxic properties against tumor cells, and again the A. gorgonum extract proved to be the most effective in inhibiting tumor growth, mainly in the CaCO2 (GI50 = 17.3 μg/mL) and AGS (GI50 = 18.2 μg/mL) cell lines. Only the ethanolic extracts of T. senegalensis and S. marginatum demonstrated anti-inflammatory activity, albeit weak (EC50 = 35 and 43 μg/mL, respectively). The present study contributed to increased knowledge about the bioactive properties of these plants commonly used in traditional medicine, some of which was discussed for the first time, opening new perspectives for their use in a wider range of health conditions, especially in African countries, where access to modern health care is more limited.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021); National funding by FCT, P.I., through the individual scientific employment program contract for L. Barros, A. Fernandes, M.I. Dias and C. Pereira. This research was funded by Fundação para a Ciência e a Tecnologia (FCT) and Aga Khan Development Network (AKDN) under the project CVAgrobiodiversity/333111699.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEssoh, Anyse P.; Liberal, Ângela; Fernandes, Ângela; Dias, Maria Inês; Pereira, Carla; Mandim, Filipa; Moldão-Martins, Margarida; Cravo, Pedro; Duarte, Maria Paula; Moura, Mónica; Romeiras, Maria M.; Barros, Lillian (2022). Evaluation of the polyphenolic composition and bioactivities of three native Cabo Verde medicinal plants. Pharmaceuticals. ISSN 1424-8247. 15:9, p. 1-13pt_PT
dc.identifier.doi10.3390/ph15091162pt_PT
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10198/28672
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBioactive propertiespt_PT
dc.subjectCabo Verdept_PT
dc.subjectEndemic medicinal plantspt_PT
dc.subjectTraditional medicinept_PT
dc.titleEvaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal Plantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1162pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLiberal
person.familyNameFernandes
person.familyNameDias
person.familyNamePereira
person.familyNameMandim
person.familyNameBarros
person.givenNameÂngela
person.givenNameÂngela
person.givenNameMaria Inês
person.givenNameCarla
person.givenNameFilipa
person.givenNameLillian
person.identifier1415151
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person.identifier.orcid0000-0002-9764-4894
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridM-8242-2013
person.identifier.ridK-1629-2016
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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