Repository logo
 
Publication

Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds

2024Journal article Open access
Simple item page
dc.contributor.authorCarpena, María
dc.contributor.authorPereira, Cláudia S.G.P.
dc.contributor.authorSilva, Aurora
dc.contributor.authorBarciela, Paula
dc.contributor.authorJorge, Ana Olívia Serra
dc.contributor.authorPerez-Vazquez, Ana
dc.contributor.authorPereira, Antia Gonzalez
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorOliveira, Maria Beatriz Prior Pinto
dc.contributor.authorPrieto Lage, Miguel A.
dc.date.accessioned2024-12-20T16:34:05Z
dc.date.available2024-12-20T16:34:05Z
dc.date.issued2024
dc.description.abstractMacroalgae are known as abundant sources of phytochemicals, which offer a plethora of beneficial biological properties. Besides being the most notable classes of compounds found in macroalgae, phlorotannins, bromophenols, and terpenoids comprise some of the most relevant for their biological properties. Phlorotannins, mainly prevalent in brown algae and structurally characterized as complex polyphenolic compounds derived from phloroglucinol units, possess robust antioxidant, anti-inflammatory, antitumor, and cytotoxic activities, modulated by factors such as the degree of polymerization and environmental conditions. Bromophenols, halogenated compounds found in algae and other marine organisms, exhibit significant antioxidant and antiviral properties. Their diverse structures and bromination patterns contribute to their potential as therapeutic and chemical defense agents. Pigments (chemically described as primary terpenoids) play a critical role in light absorption and energy transfer in macroalgae and are divided into three main groups: (i) carotenoids, which are primarily found in brown algae and provide photoprotective and antioxidant benefits; (ii) chlorophylls, known for facilitating the conversion of light into biological energy; and (iii) phycobilins, which are mostly found in red algae and play important roles in light absorption and energy transfer, besides providing remarkable health benefits. Finally, secondary terpenoids, which are particularly abundant in red algae (e.g., the Rhodomelaceae family) are central to cellular interactions and exhibit significant antioxidant, antimicrobial, antidiabetic, and anti-inflammatory properties. This study represents a detailed analysis of the biosynthesis, structural diversity, and biological activities of these macroalgae metabolites, emphasizing their potential biological properties.pt_PT
dc.description.sponsorshipThe research leading to these results was supported by Xunta de Galicia for supporting the post-doctoral grant of A.G. Pereira (IN606B-2024/011) and the pre-doctoral grant of P. Barciela (ED481A-2024-230). J.C.M. Barreira acknowledges Fundação para a Ciência e a Tecnologia (FCT) for his contract (CEECIND/04479/2017); A.O.S. Jorge and C.S.G.P. Pereira also thank FCT for their individual PhD grants (2023.00981.BD and 2021.09490.BD, respectively). Aurora silva thanks the Eu-fora Fellowship programme (EUBA-EFSA-2023-ENREL-01). In addition, the authors would like to thank the EU and the FCT for funding, through the programs (UIDP/50006/2020 DOI 10.54499/UIDP/50006/2020), and to the Ibero-American Program on Science and Technology (CYTED—GENOPSYSEN, P222RT0117).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarpena, Maria; Pereira, Cláudia S. G. P.; Silva, Aurora; Barciela, Paula; Jorge, A. Olivia S.; Perez-Vazquez, Ana; Pereira, Antia G.; Barreira, João C. M.; Oliveira, M. Beatriz P. P.; Prieto, Miguel A. (2024). Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds. Marine Drugs. ISSN 1660-3397. 22:10, p. 1-28pt_PT
dc.identifier.doi10.3390/md22100478pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10198/30777
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationNot Available
dc.relationBoosting immunity against viral infections with bioactive food constituents: validating differentiated leading trends through scholarly publications clustering maps
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMacroalgaept_PT
dc.subjectMetabolitespt_PT
dc.subjectPhlorotanninspt_PT
dc.subjectBromophenolspt_PT
dc.subjectPigmentspt_PT
dc.subjectBiological propertiespt_PT
dc.titleMetabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleBoosting immunity against viral infections with bioactive food constituents: validating differentiated leading trends through scholarly publications clustering maps
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F04479%2F2017%2FCP1403%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2023.00981.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/2021.09490.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.citation.endPage28pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume22pt_PT
oaire.fundingStreamCEEC IND 2017
oaire.fundingStreamPOR_NORTE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreira
person.familyNamePrieto Lage
person.givenNameJoão C.M.
person.givenNameMiguel A.
person.identifier107688
person.identifier.ciencia-id221E-1E00-AB74
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0002-3513-0054
person.identifier.ridD-8269-2013
person.identifier.ridG-4516-2011
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id35937495700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4629b12c-39b0-4da8-8b8d-6efba5cf2d81
relation.isAuthorOfPublication13260615-fd28-4b8b-9dd4-8a8466007579
relation.isAuthorOfPublication.latestForDiscovery4629b12c-39b0-4da8-8b8d-6efba5cf2d81
relation.isProjectOfPublication8db5a66d-019a-4046-b133-0f1122327ddd
relation.isProjectOfPublication391e8bfc-2770-4365-9293-0191afa8aada
relation.isProjectOfPublicationf9c90844-5abf-440a-9d84-9f06f488e82c
relation.isProjectOfPublication5b103ed9-66ed-4343-93cf-fcdc042b9e79
relation.isProjectOfPublication.latestForDiscovery391e8bfc-2770-4365-9293-0191afa8aada

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Metabolite Profiling of Macroalgae.pdf
Size:
2.49 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus