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Crataegus monogyna buds and fruits phenolic extracts: growth inhibitory activity on human tumor cell lines and chemical characterization by HPLC–DAD–ESI/MS

2012Journal article Open access
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dc.contributor.authorRodrigues, Sandra
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-01-04T16:35:55Z
dc.date.available2013-01-04T16:35:55Z
dc.date.issued2012
dc.description.abstractCrataegus monogyna has been extensively studied due to its various alleged health benefits. This study aimed to determine the human tumor cells growth inhibitory activity of phenolic extracts of its flower buds and fruits in three phenological stages, and further characterize the extracts by HPLC–DAD–ESI/MS. Flower bud extract showed the highest antiproliferative activity as indicated by the lowest GI50 values obtained in all the tested cell lines: MCF-7, breast adenocarcinoma; NCI-H460, non-small cell lung cancer; HeLa, cervical carcinoma; HepG2, hepatocellular carcinoma. Furthermore, porcine liver primary cell culture (PLP2) was used to evaluate toxicity to non-tumor cells. Flavonoids, particularly flavonols and flavones (higher in flower buds) and proanthocyanidins (higher in unripe fruits) were the main classes in the studied samples. Phenolic acids (mainly hydroxycinnamic acid derivatives) were also detected in significant amounts, especially in flower bud extract. Regarding anthocyanins, over ripened fruits gave the highest content. The higher bioactivity observed in flower buds might be related with its higher content in phenolic compounds.por
dc.identifier.citationRodrigues, Sandra; Calhelha, Ricardo C.; Barreira, João C.M.; Dueñas, Montserrat; Carvalho, Ana Maria; Abreu, Rui M.V.; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2012). Crataegus monogyna buds and fruits phenolic extracts: growth inhibitory activity on human tumor cell lines and chemical characterization by HPLC–DAD–ESI/MS. Food Research International. ISSN 0963-9969. 49:1, p. 516-523por
dc.identifier.doi10.1016/j.foodres.2012.07.046
dc.identifier.issn0963-9969
dc.identifier.urihttp://hdl.handle.net/10198/7823
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationNEW ANTITUMOR AND/OR ANTI-ANGIOGENIC HETEROCYCLIC COMPOUNDS: SYNTHESIS, MOLECULAR MODELLING AND INHIBITION ENZYMATIC ASSAYS USING TYROSINE KINASE MEMBRANE GROWTH FACTOR RECEPTORS
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.subjectCrataegus monogynapor
dc.subjectPhenolic profilespor
dc.subjectHuman tumor cell linespor
dc.subjectAntiproliferative activitypor
dc.titleCrataegus monogyna buds and fruits phenolic extracts: growth inhibitory activity on human tumor cell lines and chemical characterization by HPLC–DAD–ESI/MSpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleNEW ANTITUMOR AND/OR ANTI-ANGIOGENIC HETEROCYCLIC COMPOUNDS: SYNTHESIS, MOLECULAR MODELLING AND INHIBITION ENZYMATIC ASSAYS USING TYROSINE KINASE MEMBRANE GROWTH FACTOR RECEPTORS
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.endPage523por
oaire.citation.startPage216por
oaire.citation.titleFood Research Internationalpor
oaire.citation.volume49por
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
person.familyNameRodrigues
person.familyNameCalhelha
person.familyNameBarreira
person.familyNameCarvalho
person.familyNameAbreu
person.familyNameFerreira
person.givenNameSandra
person.givenNameRicardo C.
person.givenNameJoão C.M.
person.givenNameAna Maria
person.givenNameRui M.V.
person.givenNameIsabel C.F.R.
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id651F-D964-32E1
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id0F19-0DE2-12A2
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-3301-1729
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridC-6486-2008
person.identifier.ridJ-2172-2014
person.identifier.ridD-8269-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id14048942500
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id7003290613
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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