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Advisor(s)
Abstract(s)
Cholesterol (or cholest-5-en-3β-ol) is an essential component of cell membranes and also serves as the precursor for the synthesis of steroid hormones, bile acids, and vitamin D. Its total synthesis was one of the most remarkable achievements of 20th century Chemistry, accomplished almost simultaneously by Robinson in Oxford and Woodward at Harvard. This notable synthetic endeavor is on the basis of the following chapter; in which, the cholesterol structural characterization, the key aspects of its total synthesis as well as the synthesis of its unnatural enantiomer (ent-cholesterol) will be detailed addressed following a chronological perspective.
Description
Keywords
Cholesterol Chemistry Laboratory synthesis Woodward’s cholesterol Robinson’s cholesterol Ent-cholesterol
Pedagogical Context
Citation
Albuquerque, Hélio; Santos, Clementina M.M.; Silva, Artur (2022). Cholesterol chemistry and laboratory synthesis. In Anna N. Bukiya, Alex M. Dopico Cholesterol: From Chemistry and Biophysics to the Clinic. London: Elsevier, Academic Press, p. 3-24. ISBN 978-0-323-85857-1
Publisher
Elsevier, Academic Press