Publicação
Polymersomes as versatile drug delivery vesicular carriers
| dc.contributor.author | Gomes, Catarina | |
| dc.contributor.author | Bzainia, Amir | |
| dc.contributor.author | Dias, Rolando | |
| dc.contributor.author | Costa, Mário Rui | |
| dc.date.accessioned | 2023-03-01T11:24:50Z | |
| dc.date.available | 2023-03-01T11:24:50Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Stable artificial vesicles with a tiny membrane enclosing a liquid solution are generically defined as polymersomes. They are produced using amphiphilic synthetic polymers, usually block copolymers. Often, polymersomes assume a spherical geometry and their size can range from tens of nanometers up to a few microns (e.g., 50 nm!5 μm). The thickness of the membrane is generally of the order of a few nanometers (e.g., 5!20 nm) and the most common polymersomes contain in the core an aqueous solution. Fig. 11.1 depicts a typical polymersome showing a hollow sphere containing an aqueous solution in the core enclosed by a bi-layer membrane.1 The bi-layer membrane (internal/external hydrophilic coronas with a hydrophobic separating layer) is formed due to the self-assembly of an amphiphilic copolymer. The aqueous core can be used to encapsulate hydrophilic therapeutic molecules (e.g., drugs, enzymes, proteins, DNA, and RNA) while hydrophobic drugs can be loaded in the middle-layer. Homing devices, such as antibodies, can also be incorporated in the external surface of the polymersomes in order to enhance local drug release.1 Besides surface functionalization, the membrane of polymersomes can also be tailored through polymerization mechanisms such as crosslinking to enhance its hardness, if desired. | pt_PT |
| dc.description.sponsorship | Authors acknowledge to Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020) and for the Base Funding—UIDB/50020/2020 of the Associate Laboratory LSRE-LCM—funded by national funds through FCT/MCTES (PIDDAC). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Gomes, Catarina P.; Bzainia, Amir; Dias, Rolando; Costa, Mário Rui (2022). Polymersomes as versatile drug delivery vesicular carriers. In Systems of Nanovesicular Drug Delivery. London: Academic Press, cap. 11, p. 155-190. ISBN 978-0-323-91864-0 | pt_PT |
| dc.identifier.doi | 10.1016/B978-0-323-91864-0.00018-8 | pt_PT |
| dc.identifier.isbn | 978-0-323-91864-0 | |
| dc.identifier.uri | http://hdl.handle.net/10198/27354 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Academic Press | pt_PT |
| dc.relation | Mountain Research Center | |
| dc.relation | Laboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Polymersomes | pt_PT |
| dc.subject | Stable artificial vesicles | pt_PT |
| dc.title | Polymersomes as versatile drug delivery vesicular carriers | pt_PT |
| dc.type | book part | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Mountain Research Center | |
| oaire.awardTitle | Laboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT | |
| oaire.citation.endPage | 190 | pt_PT |
| oaire.citation.startPage | 155 | pt_PT |
| oaire.citation.title | Systems of Nanovesicular Drug Delivery | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Gomes | |
| person.familyName | Bzainia | |
| person.familyName | Dias | |
| person.givenName | Catarina | |
| person.givenName | Amir | |
| person.givenName | Rolando | |
| person.identifier.ciencia-id | 2B12-75A1-B8FB | |
| person.identifier.ciencia-id | 6F16-0D30-3F93 | |
| person.identifier.ciencia-id | 8417-4D84-973B | |
| person.identifier.orcid | 0000-0003-3396-3615 | |
| person.identifier.orcid | 0000-0002-1835-1066 | |
| person.identifier.orcid | 0000-0001-7369-382X | |
| person.identifier.rid | M-8552-2013 | |
| person.identifier.scopus-author-id | 57190981477 | |
| person.identifier.scopus-author-id | 7102885104 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | bookPart | pt_PT |
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