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Chemical composition and biological activity of cardoon (Cynara cardunculus L. var. altilis) seeds harvested at different maturity stages

2022Artigo científico Acesso aberto
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dc.contributor.authorMandim, Filipa
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorPinela, José
dc.contributor.authorDias, Maria Inês
dc.contributor.authorGiannoulis, Kyriakos D.
dc.contributor.authorKostić, Marina
dc.contributor.authorSoković, Marina
dc.contributor.authorQueijo, Beatriz
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2021-09-01T08:48:52Z
dc.date.available2021-09-01T08:48:52Z
dc.date.issued2022
dc.description.abstractCardoon seeds collected in Greece at four different maturity stages (samples S1 to S4) were analysed in terms of chemical composition and in vitro bioactivities. The content of phenolic compounds (six compounds in total) increased with increasing maturity, and 3,5-O-dicaffeyolquinic (14.8–33.8 mg/g extract) acid was the compound detected in higher abundance. Mature seeds (sample S4) also revealed the highest content in lipids (23 g/100 g extract) and tocopherols (29.62 mg/100 g dw) and demonstrated the highest cytotoxic (GI50 of 97–216 µg/mL) and anti-inflammatory (IC50 = 148 µg/mL) activities, and capacity to inhibit the formation of thiobarbituric acid reactive substances (TBARS) (IC50 = 5 µg/mL). Cardoon seed hydroethanolic extracts also revealed high antibacterial and antifungal potential, particularly samples S3 and S1, respectively. This study proved the multifaceted potential associated with valorisation of cardoon seeds, while their biological and chemical composition can be influenced by the maturity stage.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020); for the F. Mandim PhD grant (SFRH/BD/146614/2019) and the J. Pinela (CEECIND/01001/2018), and M.I. Dias and L. Barros contracts through the individual and institutional scientific employment program-contract. The authors are also grateful to the project TRANSCoLAB (0612_TRANS_CO_LAB_2_P), to the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project GreenHealth, Norte-01-0145-FEDER-000042, and Science and Technological Development of the Republic of Serbia (451-03-68/ 2020-14/200007). The GIP-USAL is funded by Junta de Castilla y Le´on (Spain) through the Project SA093P20 and the Strategic Research Program for Units of Excellence (ref. CLU-2018-04).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMandim, Filipa; Petropoulos, Spyridon A.; Pinela, José; Dias, Maria Inês; Giannoulis, Kyriakos D.; Kostić, Marina; Soković, Marina; Queijo, Beatriz; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.; Barros, Lillian (2022). Chemical composition and biological activity of cardoon (Cynara cardunculus L. var. altilis) seeds harvested at different maturity stages. Food Chemistry. ISSN 0308-8146. 369, p. 1-10pt_PT
dc.identifier.doi10.1016/j.foodchem.2021.130875pt_PT
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10198/23851
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Center
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCynara cardunculus (L.)pt_PT
dc.subjectCardoon seedspt_PT
dc.subjectMaturity stagept_PT
dc.subjectPhenolic compositionpt_PT
dc.subjectBioactive propertiespt_PT
dc.subjectCytotoxicitypt_PT
dc.titleChemical composition and biological activity of cardoon (Cynara cardunculus L. var. altilis) seeds harvested at different maturity stagespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00690/2020
oaire.awardNumberSFRH/BD/146614/2019
oaire.awardTitleMountain Research Center
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT
oaire.citation.startPage130875pt_PT
oaire.citation.titleFood Chemistrypt_PT
oaire.citation.volume369pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMandim
person.familyNamePinela
person.familyNameDias
person.familyNameFerreira
person.familyNameBarros
person.givenNameFilipa
person.givenNameJosé
person.givenNameMaria Inês
person.givenNameIsabel C.F.R.
person.givenNameLillian
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person.identifier.orcid0000-0002-6494-2326
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person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
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person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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