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Separation and deformation of red blood cells in PDMS microchannels

2013Book part Open access
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dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorFaustino, Vera
dc.contributor.authorPinho, Diana
dc.contributor.authorPinto, Elmano
dc.contributor.authorCidre, Diana
dc.contributor.authorYaginuma, Tomoko
dc.contributor.authorTaboada, Bruna Rafaela Pereira
dc.contributor.authorBento, David
dc.contributor.authorLima, Rui A.
dc.date.accessioned2013-09-13T08:27:35Z
dc.date.available2013-09-13T08:27:35Z
dc.date.issued2013
dc.description.abstractOver the years, several experimental techniques were performed in in vitro environments, in an attempt to understand the flow behaviour of blood in microcirculation. Several of these studies were performed in glass capillaries, and have produced significant results with respect to rheological properties of blood [1, 2]. Another way to perform in vitro blood studies is to use microchannels fabricated by soft- lithography [3, 4] and xurography [5]. With these techniques several studies have focused in the formation of the cell-free layer (CFL) that is caused by the tendency of red blood cells (RBCs) to migrate toward the centre of the microchannel, in that the physical reason is known as the Fahraeus Lindqvist. The presence of this CFL at the regions adjacent to the wall is affected by the geometry of the microchannel [4] and the physiological conditions of the working fluid, such as the hematocrit (Hct) [6], and the RBC deformability [7]. The formation of CFL can be used for separation of diseased cells from healthy blood cells [8]. The aim of this paper is to show briefly the importance of the microfluidic devices to study several physiological phenomena that happens in vivo environments with special focus on the CFL behaviour and RBC deformability.por
dc.identifier.citationRodrigues, R.; Faustino, V.; Pinho, D.; Pinto, E.; Cidre, D.; Yaginuma, T.; Taboada, B.; Bento, D.; Lima, R. (2013). Separation and deformation of red blood cells in PDMS microchannels. In Eds. Rubio-Hernández, F.J. [et al.] Perspectives in fundamental and applied rheology. ISBN 978-84-616-5245-7por
dc.identifier.isbn978-84-616-5245-7
dc.identifier.urihttp://hdl.handle.net/10198/8743
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.subjectRed blood cellpor
dc.subjectDeformationpor
dc.subjectSeparationpor
dc.subjectMicrochannelspor
dc.titleSeparation and deformation of red blood cells in PDMS microchannelspor
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.citation.conferencePlaceMalagapor
oaire.citation.titlePerspectives in fundamental and applied rheologypor
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNamePinho
person.familyNameLima
person.givenNameDiana
person.givenNameRui A.
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typebookPartpor
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relation.isAuthorOfPublication7b50c499-8095-4f4f-8b1b-fa7388e4ff62
relation.isAuthorOfPublication.latestForDiscovery7b50c499-8095-4f4f-8b1b-fa7388e4ff62
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