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Influence of mobile phase composition on the preparative separation of profens by chiral liquid chromatography

dc.contributor.authorRibeiro, António E.
dc.contributor.authorPais, Luís S.
dc.contributor.authorRodrigues, Alírio
dc.date.accessioned2010-01-31T12:33:00Z
dc.date.available2010-01-31T12:33:00Z
dc.date.issued2005
dc.description.abstractLiquid chiral chromatography of ketoprofen and flurbiprofen enantiomers is carried out using an amylose-based stationary phase. The mobile phases used for profens chiral separations are usually a hydrocarbon-alcohol combination, with high hydrocarbon content. However, profens show poor solubilities in hydrocarbon solvents when compared to alcohols. When the final objective is high productivity preparative separations, besides retention time, selectivity and column efficiency, solubility of the racemic drug is always a mandatory aspect to take into account. This work shows that an increase of the alcoholic content in the mobile phase is possible without a decrease in selectivity and column efficiency. Considering the chiral separation of ketoprofen and flurbiprofen enantiomers, results show that the mobile phase needs only a small quantity of acidic modifier and can be composed by a high or even pure alcoholic content. Additionally, it is found that the type of alcohol to be used can differ, depending on the profen racemic mixture to be separated.pt
dc.identifier.citationRibeiro, A.E.; Pais, L.S.; Rodrigues, A. (2005). Influence of mobile phase composition on the preparative separation of profens by chiral liquid chromatography. In 9th International Chemical Engineering Conference. CHEMPOR. Coimbrapt
dc.identifier.urihttp://hdl.handle.net/10198/1596
dc.language.isoengpt
dc.subjectEnantiomer separationpt
dc.subjectPreparative chromatographypt
dc.subjectMobile phase compositionpt
dc.subjectProfenspt
dc.subjectNonsteroidal anti-inflamatory drugspt
dc.titleInfluence of mobile phase composition on the preparative separation of profens by chiral liquid chromatographypt
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceCoimbra, Portugalpt
oaire.citation.titleChemPor'2005 9th International Chemical Engineering Conferencept
person.familyNameRibeiro
person.familyNamePais
person.givenNameAntónio E.
person.givenNameLuís S.
person.identifier.ciencia-id3211-D5B0-870D
person.identifier.ciencia-id421E-0CCD-A84F
person.identifier.orcid0000-0003-4569-7887
person.identifier.orcid0000-0002-3000-2862
person.identifier.scopus-author-id23390701300
person.identifier.scopus-author-id6603930478
rcaap.rightsopenAccesspt
rcaap.typeconferenceObjectpt
relation.isAuthorOfPublication52666376-f100-4407-87ef-dc5df3613761
relation.isAuthorOfPublicationc6d25534-8487-45b1-90af-d350f4e3ac55
relation.isAuthorOfPublication.latestForDiscovery52666376-f100-4407-87ef-dc5df3613761

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