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Isolation of secondary metabolites from Geranium molle L. with anticancer potential

2019Journal article Open access
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dc.contributor.authorGraça, Vânia C.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorNunes, Fernando M.
dc.contributor.authorBerthet, Jérôme
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSantos, Paulo F.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-03T17:06:45Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-03T17:06:45Z
dc.date.issued2019
dc.description.abstractTwo flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of 2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells, with only moderate hepatotoxicity.
dc.description.sponsorshipThis work was supported by European Investment Funds by FEDER/ COMPETE/POCI – Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER- 006958 and National Funds by FCT – Portuguese Foundation for Science and Technology under the projects UID/AGR/00690/2013 (CIMO) and UID/QUI/00616/2013 (CQ-VR). V.C. Graça thanks FCT for her grant (SFRH/BD/52542/2014) and L. Barros for her contract. The authors are also grateful to Interreg España-Portugal for financial support through the project 0377_Iberphenol_6_E.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGraça, V. C.; Calhelha, Ricardo C.; Nunes, Fernando M.; Berthet, Jérôme; Ferreira, Isabel C.F.R.; Santos, P. F. (2019). Isolation of secondary metabolites from Geranium molle L. with anticancer potential. Industrial Crops and Products. ISSN 0926-6690. 142, p. 1-5en_EN
dc.identifier.doi10.1016/j.indcrop.2019.111859en_EN
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/10469
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectCytotoxic activityen_EN
dc.subjectGeranium molle L.en_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectSecondary metabolitesen_EN
dc.titleIsolation of secondary metabolites from Geranium molle L. with anticancer potentialen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00616%2F2013/PT
oaire.fundingStream5876
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery2d5d1a41-7561-4a01-871c-b4c97da35053
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