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The nanoencapsulation of curcuminoids extracted from: Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities

2019Journal article Open access
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dc.contributor.authorSantos, Priscila Dayane Freitas dos
dc.contributor.authorFrancisco, Cristhian Rafael Lopes
dc.contributor.authorCoqueiro, Aline
dc.contributor.authorLeimann, Fernanda Vitória
dc.contributor.authorPinela, José
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorIneu, Rafael P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBona, Evandro
dc.contributor.authorGonçalves, Odinei Hess
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-03T17:06:44Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-03T17:06:44Z
dc.date.issued2019
dc.description.abstractCurcumin, bisdemethoxycurcumin and demethoxycurcumin are the main curcuminoids present in Curcuma longa L. and are known for their bioactivity. However, their low water solubility results in poor bioavailability and therapeutic efficacy. This work aimed to investigate the in vitro modulation capacity on the enzymes acetylcholinesterase (AChE) and glutathione S-transferase (GST), as well as the in vitro antioxidant (OxHLIA and TBARS) and anti-inflammatory activities (RAW 264.7 test) of nanoencapsulated curcuminoids. Cytotoxicity on tumor and non-tumor cell lines was also investigated. Curcuminoid nanoparticles significantly inhibited the in vitro activity of AChE (12% inhibition at 50 μM) and GST (30% inhibition at 5 μM). They presented antioxidant activity and toxic effects against breast adenocarcinoma, lung, cervical and hepatocellular carcinoma cells when dispersed in water. Encapsulated curcuminoids exhibited bioactive properties in aqueous medium (no hydrophobic solvent added), exerting antioxidant and cytotoxic effects and acting on the cholinergic and endogenous antioxidant systems.
dc.description.sponsorshipAuthors thank CNPq, CAPES and Fundação Araucária for the support. The authors are also grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (strategic project UID/AGR/00690/2013 ) and the research contracts of J. Pinela (Project AllNatt, POCI-01-0145-FEDER-030463) and R. Calhelha. To the project POCI-01-0145-FEDER-006984 – Associate Laboratory LSRE-LCM funded by FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT. This work was also funded by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project NORTE-01-0145-FEDER-023289: DeCodE and Project Mobilizador Norte-01-0247-FEDER-024479: ValorNatural®.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSantos, Priscila Dayane Freitas dos; Francisco, Cristhian Rafael Lopes; Coqueiro, Aline; Leimann, Fernanda Vitória; Pinela, José; Calhelha, Ricardo C.; Porto Ineu, Rafael; Ferreira, Isabel C.F.R.; Bona, Evandro; Gonçalves, Odinei Hess (2019). The nanoencapsulation of curcuminoids extracted from: Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities. Food and Function. ISSN 2042-6496. 10, p. 573-582en_EN
dc.identifier.doi10.1039/c8fo02431fen_EN
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/20072
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.titleThe nanoencapsulation of curcuminoids extracted from: Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activitiesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.fundingStream5876
person.familyNameLeimann
person.familyNamePinela
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameGonçalves
person.givenNameFernanda Vitória
person.givenNameJosé
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameOdinei Hess
person.identifier144781
person.identifier.ciencia-id8F10-A04D-FC0D
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-6230-9597
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9528-8187
person.identifier.ridB-4466-2014
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id9335958400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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