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Nutraceuticals and oxidative stress

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dc.contributor.authorDonn, Pauline
dc.contributor.authorSeyyedi-Mansour, Sepidar
dc.contributor.authorPerez-Vazquez, Ana
dc.contributor.authorBarciela, Paula
dc.contributor.authorFraga-Corral, Maria
dc.contributor.authorChamorro, Franklin
dc.contributor.authorCassani, Lucia
dc.contributor.authorSimal-Gandara, Jesus
dc.contributor.authorPrieto Lage, Miguel A.
dc.date.accessioned2025-01-28T11:29:58Z
dc.date.available2025-01-28T11:29:58Z
dc.date.issued2024
dc.description.abstractSeveral studies have found a link between oxidative stress and a variety of noncommunicable diseases including diabetes, obesity, aging, Down syndrome, cancers, cardiovascular, and neurodegenerative diseases. All these pathologies are aided by oxidative stress, which is caused by the excessive production of free radicals or insufficient elimination of free radicals. To avoid, reduce, or eliminate this imbalance favoring prooxidants in organs and cells, one of the healthier and promising approaches is to use antioxidant compounds like nutraceuticals, which can scavenge the excessive free radicals and restore the balance. Nutraceuticals are dietary compounds that include dietary fibers, prebiotics, probiotics, polyunsaturated fatty acids, vitamins, minerals, polyphenols, and spices. Some of them have antioxidant activity, which can react with the free electron available in the outer layer of free radicals to make the unstable compounds more stable while avoiding free radicals’ proliferation and the induced damage to the different metabolisms that occur in the human body because of oxidative stress. Thus, each nutraceutical class performs specific functions in managing the onset of oxidative stress. Therefore, the purpose of this chapter is to sort out the mechanisms by which different classes of nutraceuticals can have beneficial effects on oxidative stress and related pathologies via their biological properties. However, it also observes that the efficacy of nutraceutical compounds can only be guaranteed if they can maintain their properties during production, preservation, consumption, digestion, and use by the various targeted active sites. Thus, it shows that the concepts of bioavailability and bio-accessibility are key factors for the effectiveness of nutraceuticals on oxidative stress when consumed by humans.pt_PT
dc.description.sponsorshipThe research leading to these results was supported by MICINN supporting the Ramón y Cajal grant for M.A. Prieto (RYC-2017-22891) and by Xunta de Galicia for supporting the program EXCELENCIA-ED431F 2020/12 and the postdoctoral grant of L. Cassani (ED481B-2021/152). Authors are grateful to Ibero-American Program on Science and Technology (CYTED—AQUA-CIBUS, P317RT0003), and to the Bio-Based Industries Joint Undertaking (JU) under grant agreement No 888003 UP4HEALTH Proj- ect (H2020-BBI-JTI-2019). The JU receives support from the European Union’s Horizon 2020 research and innovation program and the Bio-Based Industries Consortium.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDonn, Pauline; Seyyedi-Mansour, Sepidar; Perez-Vazquez, Ana; Barciela, Paula; Fraga-Corral, Maria; Chamorro, Franklin; Cassani, Lucia; Simal-Gandara, Jesus; Prieto Lage, Miguel A. (2024). Nutraceuticals and oxidative stress. In Nutraceuticals: A Holistic Approach to Disease Prevention. Berlin: Walter de Gruyter, p. 125-144. ISBN 978-311131760-1pt_PT
dc.identifier.doi10.1515/9783111317601-006pt_PT
dc.identifier.isbn978-311131760-1
dc.identifier.issn978-311131730-4
dc.identifier.urihttp://hdl.handle.net/10198/31081
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWalter de Gruyterpt_PT
dc.relationSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidants
dc.subjectElectrons
dc.subjectFree radicals
dc.subjectNeurodegenerative diseases
dc.subjectPathology
dc.subjectPolyunsaturated fatty acids
dc.subjectProbiotics
dc.titleNutraceuticals and oxidative stresspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleSustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/888003/EU
oaire.citation.endPage144pt_PT
oaire.citation.startPage125pt_PT
oaire.citation.titleNutraceuticals: A Holistic Approach to Disease Preventionpt_PT
oaire.fundingStreamH2020
person.familyNameFraga-Corral
person.familyNamePrieto Lage
person.givenNameMaria
person.givenNameMiguel A.
person.identifier1054547
person.identifier107688
person.identifier.ciencia-id1616-98AD-4546
person.identifier.ciencia-id221E-1E00-AB74
person.identifier.orcid0000-0002-5663-9239
person.identifier.orcid0000-0002-3513-0054
person.identifier.ridG-7335-2017
person.identifier.ridG-4516-2011
person.identifier.scopus-author-id56346469200
person.identifier.scopus-author-id35937495700
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication446f0a90-be7c-4111-9949-42475fda0e6a
relation.isAuthorOfPublication13260615-fd28-4b8b-9dd4-8a8466007579
relation.isAuthorOfPublication.latestForDiscovery446f0a90-be7c-4111-9949-42475fda0e6a
relation.isProjectOfPublication9980c0d6-0317-49a0-a44d-b8aedf2294a5
relation.isProjectOfPublication.latestForDiscovery9980c0d6-0317-49a0-a44d-b8aedf2294a5

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