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The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Review

2024Journal article Open access
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dc.contributor.authorFonseca, Jéssica
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorRicardo, Sara
dc.date.accessioned2024-06-27T14:02:36Z
dc.date.available2024-06-27T14:02:36Z
dc.date.issued2024
dc.description.abstractChemoresistance is a challenge in cancer treatment, limiting the effectiveness of chemotherapy. Mushroom extracts have shown potential as treatments for cancer therapies, offering a possible solution to overcome chemoresistance. This systematic review aimed to explore the role of mushroom extracts in enhancing chemotherapy and reversing chemoresistance in cancer cells. We searched the PubMed, Web of Science and Scopus databases, following the PRISMA guidelines, and registered on PROSPERO. The extracts acted by inhibiting the proliferation of cancer cells, as well as enhancing the effect of chemotherapy. The mechanisms by which they acted included regulating anti-apoptotic proteins, inhibiting the JAK2/STAT3 pathway, inhibiting the ERK1/2 pathway, modulating microRNAs and regulating p-glycoprotein. These results highlight the potential of mushroom extracts to modulate multiple mechanisms in order to improve the efficacy of chemotherapy. This work sheds light on the use of mushroom extracts as an aid to chemotherapy to combat chemoresistance. Although studies are limited, the diversity of mushrooms and their bioactive compounds show promising results for innovative strategies to treat cancer more effectively. It is crucial to carry out further studies to better understand the therapeutic potential of mushroom extracts to improve the efficacy of chemotherapy in cancer cells.pt_PT
dc.description.sponsorshipThe Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) is gratefully acknowledged for the PhD grant, no. BD/DCB/CESPU/01/2023, to Jéssica Fonseca.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFonseca, Jéssica, Vaz, Josiana A., Ricardo, Sara (2024). The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Review. Cells. ISSN 2073-4409. 13:6, p. 1-24pt_PT
dc.identifier.doi10.3390/cells13060510pt_PT
dc.identifier.issn2073-4409
dc.identifier.urihttp://hdl.handle.net/10198/29964
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnticancer therapiespt_PT
dc.subjectCancerpt_PT
dc.subjectChemoresistancept_PT
dc.subjectDrug resistancept_PT
dc.subjectMushroom extractspt_PT
dc.subjectSynergypt_PT
dc.titleThe Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage24pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleCellspt_PT
oaire.citation.volume13pt_PT
person.familyNameVaz
person.givenNameJosiana A.
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.orcid0000-0002-6989-1169
person.identifier.scopus-author-id16305323200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1c1a2cb9-5a36-47ba-bca0-ffcbef28df18
relation.isAuthorOfPublication.latestForDiscovery1c1a2cb9-5a36-47ba-bca0-ffcbef28df18

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