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Administration of Castanea sativa flowers extract in Wistar rats

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dc.contributor.authorNascimento-Gonçalves, Elisabete
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorFardilha, Margarida
dc.contributor.authorFerreira, Rita
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorRocha, Ana Isabel Faustino
dc.contributor.authorRosa, Eduardo
dc.contributor.authorBruno Jorge
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2019-06-19T14:51:16Z
dc.date.available2019-06-19T14:51:16Z
dc.date.issued2019
dc.description.abstractCastanea sativa Mill. flowers (CF) are reported by ancestral claims as having health benefits like mucolytic, antispasmodic and anti-dysenteric properties and, in vitro studies showed anticancer properties against breast, colon, cervical and hepatocellular carcinomas [1]. The aim of this work was to study the effect of chestnut flowers (CF) extract on rat’s physiological parameters. Fifteen male Wistar Unilever rats were randomly divided into two groups: untreated control, n=10, and CF group, n=5. Animals from CF group were exposed to the chestnut flowers extract in drinking water (20 mg/animal/day) for 49 weeks. Body weight, food and drink consumption were measured weekly. At necropsy, all organs were collected, weighed and liver and kidney were processed for histological analysis. Animals from CF group showed a mean final body weight and a food consumption higher than untreated animals (p>0.05). Animals from CF group showed lower consumption of water (p=0.000). Relative mean liver weight from animals treated with CF was higher than untreated animals (p=0.026) and presented more liver degeneration. However, liver inflammatory infiltrate was reduced (p=0.026) in animals exposed to CF extract. There were no significant differences in relative mean kidney weight among groups. Untreated animals developed 50% of discrete proteinuria and CF treated animals developed 20%. Serum levels of albumin, total protein, glucose and alanine aminotransferase did not show significant differences between experimental groups. These results suggest that chestnut flowers extract was well tolerated by the animals, did not cause hepatic and kidney toxicity and had no effect on biochemical profile. Further studies are necessary to evaluate in vivo, the effect of different CF doses and evaluate the respective potential use.pt_PT
dc.description.sponsorshipThis work was supported by European Investment Funds by FEDER/ COMPETE/POCI - Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER006958 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013, UID/AGR/00690/2013, UID/AGR/0433/2019, UID/AGR/00690/2019, PTDC/DES/114122/2009 and the project PTDC/DTP-DES/6077/2014 and post-graduation grant SFRH/BD/136747/2018. Funding: Interreg Program for the financial support of the Project IBERPHENOL, Project Number 0377_IBERPHENOL_6_E, co-financed by European Regional Development Fund (ERDF) through POCTEP 2014-2020.”pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNascimento-Gonçalves, Elisabete; Seixas, Fernanda; Fardilha, Margarida; Ferreira, Rita; Neuparth, Maria João; Faustino-Rocha, Ana I.; Eduardo, Rosa; Colaço, Bruno; Ferreira, Isabel C.F.R.; Oliveira, Paula A. (2019). Administration of Castanea sativa flowers extract in Wistar rats. In XX EuroFoodChem Conference. Porto. ISBN 978-989-8124-26-5pt_PT
dc.identifier.isbn978-989-8124-26-5
dc.identifier.urihttp://hdl.handle.net/10198/19351
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationUID/AGR/0433/2019pt_PT
dc.relationMountain Research Centre
dc.relationBiochemical, morphological and functional evaluation of breast cancer-induced muscle wasting: the role of exercise training
dc.relationRUNNING away from prostate cancer: WALKING through the molecular basis of physical activity
dc.relationalterado para: “Contribuição para o estudo do cancro da próstata: influência do estilo de vida num modelo animal Contribution to the study of prostate cancer: lifestyle influence in an animal model”. Estudo do impacto da atividade física no microambiente do cancro da próstata num modelo animal
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleAdministration of Castanea sativa flowers extract in Wistar ratspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Centre
oaire.awardTitleBiochemical, morphological and functional evaluation of breast cancer-induced muscle wasting: the role of exercise training
oaire.awardTitleRUNNING away from prostate cancer: WALKING through the molecular basis of physical activity
oaire.awardTitlealterado para: “Contribuição para o estudo do cancro da próstata: influência do estilo de vida num modelo animal Contribution to the study of prostate cancer: lifestyle influence in an animal model”. Estudo do impacto da atividade física no microambiente do cancro da próstata num modelo animal
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F04033%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FDES%2F114122%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FDTP-DES%2F6077%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F136747%2F2018/PT
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.titleXX EuroFoodChem Conferencept_PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876-PPCDTI
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamFARH
person.familyNameFerreira
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
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