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Phytochemical characterization and bioactive properties of Osyris quadripartita Salzm. ex Decne. leaves from Algeria

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dc.contributor.authorRached, Wahiba
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorBennaceur, Malika
dc.contributor.authorMarouf, Abderrazak
dc.contributor.authorBarros, Lillian
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2016-12-21T11:00:51Z
dc.date.available2016-12-21T11:00:51Z
dc.date.issued2016
dc.description.abstractMedicinal plants are sources of bioactive compounds with recognized beneficial effects on human health. An example is Osyris quadripartita, also known as Osyris lanceolata, which is known for its traditional therapeutic properties in some African countries. The aim of the present study was to evaluate the antioxidant (free radical scavenging activity, reducing power and lipid peroxidation inhibition), antiinflammatory (inhibition of NO production in lipopolysaccharide-stimulated RAW 264.7 macrophages) and cytotoxic (in a panel of human tumor cell lines and in non-tumor porcine liver primary cells) properties of O. quadripartita, providing a phytochemical characterization of its aqueous extracts and different organic fractions, by using high-performance liquid chromatography coupled to diode array detection and electrospray ionisation mass spectrometry (HPLC-DAD-ESI/MS). Twenty-eight individual phenolic compounds were identified: fifteen flavan-3-ols, six flavones, four flavonols, two phenolic acids and one flavanone derivative. The most abundant compounds in the ethyl acetate fraction were (+)-catechin and procyanidin dimer B1 (EC-4,8-C). Quercetin-3-O-rutinoside was the major compound in both the n-butanol fraction and crude aqueous extract. In most of the samples and assays the antioxidant activity was higher than the one revealed by the positive control gallic acid, with the highest antioxidant activity observed in the ethyl acetate fraction. The same fraction also showed the highest inhibition of NO production and the highest cytotoxicity against MCF-7 and NCI-H460 cell lines. This study highlights the potential of O. quadripartita fractions rich in phenolic compounds to be used in pharmaceutical and cosmetic fields.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programe PT2020 for nancial support to CIMO (UID/AGR/00690/2013), LSRE (Project UID/EQU/50020/2013), A. Fernandes (SFRH/BD/76019/2011), R. C. Calhelha (SFRH/BPD/68344/2010) and L. Barros (SFRH/BPD/107855/2015) grants. The authors also thank the University Oran 1, the University Abdelhamid Ibn Badis Mostaganem and the LRZA (Algeria) for nancial support of this research work.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRached, Wahiba; Calhelha, Ricardo C.; Fernandes, Ângela; Carvalho, Ana Maria; Bennaceur, Malika; Marouf, Abderrazak; Barros, Lillian; Santos-Buelga, Celestino Ferreira, Isabel C.F.R. (2016). Phytochemical characterization and bioactive properties of Osyris quadripartita Salzm. ex Decne. leaves from Algeria. RSC Advances. ISSN 2046-2069. 6:76, p. 72768-72776pt_PT
dc.identifier.doi10.1039/C6RA11787Bpt_PT
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/10198/13638
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationLSRE - Laboratory of Separation and Reaction Engineering
dc.relationComprehensive study of the effects of rays and electron beam in wild mushrooms: physico-chemical, nutritional and bioactive parameters
dc.relationNew antitumor and/or anti-angiogenic heterocyclic compounds: Synthesis, molecular modelling and inhibition enzymatic assays using tyrosine kinase membrane growth factor receptors
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.relationMountain Research Centre - UID/AGR/00690/2013
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePhytochemical characterization and bioactive properties of Osyris quadripartita Salzm. ex Decne. leaves from Algeriapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/EQU/50020/2013
oaire.awardNumberSFRH/BD/76019/2011
oaire.awardNumberSFRH/BPD/68344/2010
oaire.awardNumberSFRH/BPD/107855/2015
oaire.awardNumberUID/AGR/00690/2013
oaire.awardTitleLSRE - Laboratory of Separation and Reaction Engineering
oaire.awardTitleComprehensive study of the effects of rays and electron beam in wild mushrooms: physico-chemical, nutritional and bioactive parameters
oaire.awardTitleNew antitumor and/or anti-angiogenic heterocyclic compounds: Synthesis, molecular modelling and inhibition enzymatic assays using tyrosine kinase membrane growth factor receptors
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardTitleMountain Research Centre - UID/AGR/00690/2013
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FEQU%2F50020%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F76019%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F107855%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.endPage72776pt_PT
oaire.citation.issue76pt_PT
oaire.citation.startPage72768pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume6pt_PT
oaire.fundingStream5876
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStream6817 - DCRRNI ID
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person.givenNameRicardo C.
person.givenNameÂngela
person.givenNameAna Maria
person.givenNameLillian
person.givenNameIsabel C.F.R.
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person.identifier.orcid0000-0002-6801-4578
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person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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