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Phenolic profile and bioactive potential of cardoon (Cynara cardunculus L.) inflorescences: selection of the best genotype for food application

2022Conference object Open access
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dc.contributor.authorMandim, Filipa
dc.contributor.authorPinela, José
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarracosa, Paulo
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2023-11-16T15:38:06Z
dc.date.available2023-11-16T15:38:06Z
dc.date.issued2022
dc.description.abstractCynara cardunculus L. (syn. cardoon) belongs to the Asteraceae family and is native to the Mediterranean basin. This species is widely used for milk coagulation of PDO cheeses and consumed due to its rich nutritional value and related medicinal properties (e.g. choleretic, cardiotonic, antidiabetic, liver disease treatment). In the last decade, the interest in this crop increases due to its multifaceted industrial applications. It has been explored for animal feed and lightwood panels, biodiesel, paper pulp, and food oil production. Their production countries estimate a generation of approximatly 15 to 30 t/ha of dry biomass. The adequate exploitation and characterization of the species are essential for circular economic stimulation and environmental impact reduction. The hydroethanolic extracts of four cardoon genotypes and their vegetable tissues (stigma, corolla, bracts, pappus, receptacle) were studied. The polyphenolic profile was analyzed by HPLC-DAD-ESI/MS. The antioxidant activity was evaluated TBARS and OxHLIA cell-based assays.The anti-inflammatory activity was assessed through the extracts’ capacity to inhibit the pro-inflammatory mediator nitric oxide. Finally, the cytotoxic potential was evaluated against four tumor and a non-tumor cell line (PLP2) using the sulforhodamine B assay. Fourteen phenolic compounds were tentatively identified. The corolla presented the higher variety and bracts the higher content of phenolic compounds. In terms of bioactivity, none of the tested extracts exhibit anti-inflammatory potential. Genotype F1-1-1 exhibits a higher cytotoxic potential. All the four genotypes and vegetable tissues tested exhibited antioxidant capacity, especially corolla of F4-1-4 genotype for TBARS assay (IC50 = 38 μg/mL) and its receptacle for OxHLIA (IC50 = 71 μg/mL). In conclusion, this study showed that the phenolic composition and biological activities of cardoon are influenced by both genotype and plant tissue. Further studies are needed to determine the genetic information for obtaining the highest bioactivity.pt_PT
dc.description.sponsorshipTo the Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021); PhD grant of Filipa Mandim (SFRH/146614/2019) and J. Pinela (CEECIND/01011/2018), M.I. Dias and L. Barros contracts.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMandim, Filipa; Pinela, José; Dias, Maria Inês; Barracosa, Paulo; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.; Barros, Lillian (2022). Phenolic profile and bioactive potential of cardoon (Cynara cardunculus L.) inflorescences: selection of the best genotype for food application. In 12º Encontro Nacional de Cromatografia. Aveiropt_PT
dc.identifier.isbn978-989-8124-37-1
dc.identifier.urihttp://hdl.handle.net/10198/28891
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Químicapt_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCynara cardunculus L.pt_PT
dc.titlePhenolic profile and bioactive potential of cardoon (Cynara cardunculus L.) inflorescences: selection of the best genotype for food applicationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01011%2F2018%2FCP1578%2FCT0002/PT
oaire.citation.conferencePlaceAveiropt_PT
oaire.citation.endPage114pt_PT
oaire.citation.startPage114pt_PT
oaire.citation.title12º Encontro Nacional de Cromatografiapt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
person.familyNameMandim
person.familyNamePinela
person.familyNameDias
person.familyNameFerreira
person.familyNameBarros
person.givenNameFilipa
person.givenNameJosé
person.givenNameMaria Inês
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifier144781
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
person.identifier.ridM-8242-2013
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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