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Unravelling phytochemical and bioactive potential of three hypericum species from romanian spontaneous flora: H. alpigenum, H. perforatum and H. rochelii

2022Artigo científico Acesso aberto
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dc.contributor.authorBabotă, Mihai
dc.contributor.authorFrumuzachi, Oleg
dc.contributor.authorMocan, Andrei
dc.contributor.authorTamas, Mircea
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPinela, José
dc.contributor.authorStojković, Dejan
dc.contributor.authorSoković, Marina
dc.contributor.authorBadarau, Alexandru Sabin
dc.contributor.authorCrisan, Gianina
dc.contributor.authorBarros, Lillian
dc.contributor.authorPaltinean, Ramona
dc.date.accessioned2023-03-03T14:56:13Z
dc.date.available2023-03-03T14:56:13Z
dc.date.issued2022
dc.description.abstractHypericum perforatum L., also known as St. John's Wort, is recognized worldwide as a valuable medicinal herb; however, other Hypericum species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literature, a comparative evaluation between H. alpigenum Kit., H. perforatum L. and H. rochelii Griseb. & Schenk was conducted in the present study. Two types of herbal preparations obtained from the aerial parts of these species were analyzed: extracts obtained through maceration and extracts obtained through magnetic-stirring-assisted extraction. LC-DAD-ESI-MSn analysis revealed the presence of phenolic acids, flavan-3-ols and flavonoid derivatives as the main constituents of the above-mentioned species. Moreover, all extracts were tested for their antioxidant, enzyme-inhibitory and antimicrobial potential. Our work emphasizes for the first time a detailed description of H. rochelii phenolic fractions, including their phytochemical and bioactive characterization. In comparison with the other two studied species, H. rochelii was found as a rich source of phenolic acids and myricetin derivatives, showing important antioxidant, anticholinesterase and antibacterial activity. The study offers new perspectives regarding the chemical and bioactive profile of the less-studied species H. alpigenum and H. rochelii.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBabotă, Mihai; Frumuzachi, Oleg; Mocan, Andrei; Tamas, Mircea; Dias, Maria Inês; Pinela, José; Stojković, Dejan; Soković, Marina; Badarau, Alexandru Sabin; Crisan, Gianina; Barros, Lillian; Paltinean, Ramona. (2022). Unravelling phytochemical and bioactive potential of three hypericum species from romanian spontaneous flora: H. alpigenum, H. perforatum and H. rochelii. Plants. EISSN 2223-7747. 11:20, p. 1-17pt_PT
dc.identifier.eissn2223-7747
dc.identifier.urihttp://hdl.handle.net/10198/27452
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHypericum speciespt_PT
dc.subjectHypericum rocheliipt_PT
dc.subjectHypericum alpigenum
dc.subjectAntioxidant activity
dc.subjectEnzyme inhibition
dc.titleUnravelling phytochemical and bioactive potential of three hypericum species from romanian spontaneous flora: H. alpigenum, H. perforatum and H. rocheliipt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePlantspt_PT
person.familyNameDias
person.familyNamePinela
person.familyNameBarros
person.givenNameMaria Inês
person.givenNameJosé
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridM-8242-2013
person.identifier.ridB-4466-2014
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication706cd9ff-065b-4c98-98a7-5c0a9e45adc4
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01

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