Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.

Pereira, Olívia R.; Macias, Rócio I.R.; Domingues, Maria R.M.; Marin, Jose J.G.; Cardoso, Susana M.

Publication

Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.

2019Journal article

dc.contributor.author	Pereira, Olívia R.
dc.contributor.author	Macias, Rócio I.R.
dc.contributor.author	Domingues, Maria R.M.
dc.contributor.author	Marin, Jose J.G.
dc.contributor.author	Cardoso, Susana M.
dc.date.accessioned	2019-10-23T11:24:32Z
dc.date.available	2019-10-23T11:24:32Z
dc.date.issued	2019
dc.description.abstract	The phenolic composition of hydroethanolic extracts of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro . L. cardiaca extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol-O-rutinoside were the major phenolic compounds of L. dentata and M. aquatica extracts, accounting for 68 ± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. While L. cardiaca extract showed moderate biological effects, M. aquatica extract displayed high antioxidant activity in chemical models, and that of L. dentata was effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover, M. aquatica extract (50 μg/mL) and its mixture (50%/50%) with L. dentata extract displayed an effective cytoprotective effect.	pt_PT
dc.description.sponsorship	Aveiro and FCT/MCT financed the QOPNA research Unit (FCT UID/QUI/00062/2019) through national funds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, to the Portuguese NMR Network and to the Portuguese Mass Spectrometry Network (RNEM, LISBOA-01-0145-FEDER-402-022125). This study was supported in part by the CIBERehd (EHD15PI05/2016) and Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain (PI16/00598, co-funded by European Regional Development Fund/European Social Fund, “Investing in your future”); Spanish Ministry of Economy, Industry and Competitiveness (SAF2016-75197-R); Junta de Castilla y Leon (SA063P17); AECCScientific Foundation (2017/2020), Spain; and “Centro Internacional sobre el Envejecimiento” (OLD-HEPAMARKER, 0348_CIE_6_E), Spain. Project AgroForWealth (CENTRO-01-0145-FEDER-000001) funded by Centro2020, through FEDER and PT2020, financed the research contract of Susana M. Cardoso.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Pereira, Olívia R.; Macias, Rocio I.R.; Domingues, Maria R.M.; Marin, Jose J.G.; Cardoso, Susana M. (2019). Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L. Antioxidants. ISSN 2076-3921. 8:8, p. 1-13	pt_PT
dc.identifier.doi	10.3390/antiox8080267	pt_PT
dc.identifier.issn	2076-3921
dc.identifier.uri	http://hdl.handle.net/10198/19688
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	MDPI	pt_PT
dc.relation	Organic Chemistry, Natural Products and Food Stuffs
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	pt_PT
dc.subject	Mentha	pt_PT
dc.subject	Lavandula	pt_PT
dc.subject	Leonurus	pt_PT
dc.subject	Liver diseases	pt_PT
dc.subject	HepG2 cells	pt_PT
dc.subject	Antioxidant;	pt_PT
dc.subject	Phenolic compounds	pt_PT
dc.subject	UHPLC-DAD-ESI-MSn	pt_PT
dc.title	Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Organic Chemistry, Natural Products and Food Stuffs
oaire.awardURI	info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00062%2F2019/PT
oaire.citation.conferencePlace	Switzerland	pt_PT
oaire.citation.issue	8	pt_PT
oaire.citation.startPage	267	pt_PT
oaire.citation.title	Antioxidants	pt_PT
oaire.citation.volume	8	pt_PT
oaire.fundingStream	6817 - DCRRNI ID
person.familyName	Pereira
person.givenName	Olívia R.
person.identifier	145216
person.identifier.ciencia-id	B312-AF21-D2FA
person.identifier.orcid	0000-0002-6275-3134
person.identifier.rid	H-1049-2014
person.identifier.scopus-author-id	52264387000
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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