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In vitro digestion and bioaccessibility studies of vitamin E-loaded nanohydroxyapatite Pickering emulsions and derived fortified foods

2022Artigo científico Acesso aberto
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dc.contributor.authorRibeiro, Andreia
dc.contributor.authorGonçalves, Raquel F.S.
dc.contributor.authorPinheiro, Ana C.
dc.contributor.authorManrique, Yaidelin A.
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorLopes, José Carlos B.
dc.contributor.authorDias, Madalena M.
dc.date.accessioned2021-11-17T15:50:02Z
dc.date.available2021-11-17T15:50:02Z
dc.date.issued2022
dc.description.abstractVitamin E is a lipophilic vitamin playing an essential role in human health. Due to oxidative instability, it presents fast degradation and bioactivity loss. In this study, vitamin E-loaded Pickering emulsions (PEs) stabilized by nano-hydroxyapatite (n-HAp) were produced using a static mixer (NETmix), a technique enabling continuous production and droplet size tailoring. Thus, oil-in-water (O/W) emulsions containing vitamin E at a content of 1 mg/mL were produced with different droplet sizes (7.53, 11.56 and 17.72 μm) using an O/W ratio of 20/80 (v/v). Their stability during in vitro gastrointestinal digestion and vitamin E bioaccessibility were investigated. It was observed that n-HAp particles disrupt in the stomach and subsequently aggregate as random calcium phosphates in the small intestine, leading to low vitamin E bioaccessibility due to oil entrapment. The emulsion showing the highest vitamin E bioaccessibility (3.29 ± 0.57%, sample with the larger average droplet size) was used to produce fortified gelatine and milk, resulting in an increased bioaccessibility (10.87 ± 1.04% and 18.07 ± 2.90%, respectively). This fact was associated with the presence of macronutrients and the lower n- HAp content. Overall, n-HAp PEs offer advantages for vitamin E encapsulation directed to fortified foods development, a process able to be extended to other lipophilic vitamins.pt_PT
dc.description.sponsorshipThis work was financially supported by Base Funding - UIDB/50020/2020 of the Associate Laboratory LSRE-LCM - funded by national funds through FCT/MCTES (PIDDAC), Base Funding - UIDB/00690/2020 of CIMO - funded by national funds through FCT/MCTES (PIDDAC), and Base Funding - UIDB/04469/2020 of the CEB funded by national funds through FCT. Andreia Ribeiro acknowledges her PhD fellowship funded by Project NORTE-08-5369-FSE-000028, supported by N2020, under PT2020, through ESF, and Raquel F. Gonçalves acknowledges the Foundation for Science and Technology (FCT) for their fellowship (SFRH/BD/140182/2018). Authors thank Fluidinova S.A. for providing samples of nanoXIM-CarePaste and Instituto de Investigação e Inovação em Saúde (i3S) for the services provided with CLSM analysis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, Andreia; Gonçalves, Raquel F.S.; Pinheiro, Ana C.; Manrique, Yaidelin A.; Barreiro, M.F.; Lopes, José Carlos B.; Dias, Madalena M. (2022). In vitro digestion and bioaccessibility studies of vitamin E-loaded nanohydroxyapatite Pickering emulsions and derived fortified foods. LWT - Food Science and Technology. ISSN 0023-6438. 154, p. 1-9pt_PT
dc.identifier.doi10.1016/j.lwt.2021.112706pt_PT
dc.identifier.issn0023-6438
dc.identifier.urihttp://hdl.handle.net/10198/24214
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNETmixpt_PT
dc.subjectPickering emulsionspt_PT
dc.subjectLipophilic vitaminpt_PT
dc.subjectIn vitro digestionpt_PT
dc.titleIn vitro digestion and bioaccessibility studies of vitamin E-loaded nanohydroxyapatite Pickering emulsions and derived fortified foodspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage112706pt_PT
oaire.citation.titleLWT - Food Science and Technologypt_PT
oaire.citation.volume154pt_PT
person.familyNameBarreiro
person.givenNameFilomena
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id57188719717
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0391987c-ba90-488b-839a-153447ce1f0f
relation.isAuthorOfPublication.latestForDiscovery0391987c-ba90-488b-839a-153447ce1f0f

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