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Meta-analysis of antimicrobial activity of Allium, Ocimum, and Thymus spp. confirms their promising application for increasing food safety

2024Journal article Open access
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dc.contributor.authorBonilla-Luque, Olga María
dc.contributor.authorSilva, Beatriz Nunes
dc.contributor.authorEzzaky, Youssef
dc.contributor.authorPossas, Arícia
dc.contributor.authorAchemchem, Fouad
dc.contributor.authorCadavez, Vasco
dc.contributor.authorGonzales-Barron, Ursula
dc.contributor.authorValero, Antonio
dc.date.accessioned2024-06-13T11:29:35Z
dc.date.available2024-06-13T11:29:35Z
dc.date.issued2024
dc.description.abstractBiopreservation strategies such as the use of Mediterranean plant extracts to ensure food safety are promising to deal with the emergence of antimicrobial resistances and the overreliance on food chemical additives. In the last few decades, antimicrobial susceptibility testing (AST) for evaluating the in vitro antibacterial potential of plant extracts against the most relevant foodborne pathogens has been widely reported in the literature. The current meta-analysis aimed to summarise and analyse the extensive evidence available in the literature regarding the in vitro antimicrobial capability of Allium, Ocimum and Thymus spp. extracts against foodborne pathogens. A systematic review was carried out to gather data on AST results of these extracts against Listeria monocytogenes, Staphylococcus aureus, Salmonella spp., Escherichia coli and Bacillus cereus, including inhibition diameters (ID) and minimum inhibitory concentrations (MIC). A total of 742 records were gathered from a raw collection of 2,065 articles. Weighted mixed-effect linear models were adjusted to data to obtain pooled ID, pooled MIC and the relationship between both model estimations and observations. The pooled results revealed B. cereus as the most susceptible bacteria to Allium sativum (pooled ID = 20.64 ± 0.61 mm) by diffusion methods and S. aureus (pooled MIC = 0.146 mg/mL) by dilution methods. Diffusion methods did not yield conclusive results for Ocimum spp. extracts; however, the lowest pooled MIC was obtained for S. aureus (0.263 mg/mL). Among the foodborne pathogens evaluated, B. cereus showed the highest sensitivity to Thymus spp. extracts by both diffusion and dilution methods (pooled ID = 28.90 ± 2.34 mm and MIC = 0.075 mg/mL). The methodology used for plant extraction was found to not significantly affect MIC values (p > 0.05). Overall, the antimicrobial effectiveness of the studied extracts against Gram-positive and Gram-negative bacteria was demonstrated. Finally, the robustness of the meta-regression model was confirmed, also revealing an inversely proportional correlation between the ID and MIC measurements (p < 0.0001). These results provide a robust scientific basis on the factors affecting the in vitro antimicrobial efficacy of extracts from Mediterranean plants. They also provide valuable information for stakeholders involved in their industrial application in food, including producers, regulatory agencies and consumers which demand green-labelled foods.pt_PT
dc.description.sponsorshipThe authors are grateful to EU PRIMA program and the International Joint Programming (Project Reference PCI2019-103453) R&D Projects 2019 from the Spanish Ministry of Science and Innovation (Plan Estatal de Investigación Científica y T´ecnica y de Innovaci´on 2017–2020: State R&D Program Oriented to the Challenges of the Society) for funding the ArtiSaneFood project (PRIMA/0001/2018). The authors also wish to thank the Moroccan Ministry of Higher Education, Scientific Research and Innovation (MESRSI) and the Portuguese Foundation for Science and Technology (FCT). Funding for open access charge: Universidad de Córdoba / CBUA.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBonilla-Luque, Olga María; Silva, Beatriz Nunes; Ezzaky, Youssef; Possas, Arícia; Achemchem, Fouad; Cadavez, Vasco; Gonzales-Barron, Úrsula; Valero, Antonio (2024). Meta-analysis of antimicrobial activity of Allium, Ocimum, and Thymus spp. confirms their promising application for increasing food safety. Food Research International. ISSN 0963-9969. 188, 1-10pt_PT
dc.identifier.doi10.1016/j.foodres.2024.114408pt_PT
dc.identifier.issn0963-9969
dc.identifier.urihttp://hdl.handle.net/10198/29901
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiopreservationpt_PT
dc.subjectInhibition diameterpt_PT
dc.subjectMediterranean extractspt_PT
dc.subjectMeta-regressionpt_PT
dc.subjectMICpt_PT
dc.titleMeta-analysis of antimicrobial activity of Allium, Ocimum, and Thymus spp. confirms their promising application for increasing food safetypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PRIMA Section 2 - Multi-topic 2018/PRIMA%2F0001%2F2018/PT
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFood Research Internationalpt_PT
oaire.citation.volume188pt_PT
oaire.fundingStreamPRIMA Section 2 - Multi-topic 2018
person.familyNameNunes Silva
person.familyNameCadavez
person.familyNameGonzales-Barron
person.givenNameBeatriz
person.givenNameVasco
person.givenNameUrsula
person.identifierR-000-HDG
person.identifier.ciencia-id3A1B-9D91-31B4
person.identifier.ciencia-id441B-01AB-A12E
person.identifier.ciencia-id0813-C319-B62A
person.identifier.orcid0000-0002-7571-031X
person.identifier.orcid0000-0002-3077-7414
person.identifier.orcid0000-0002-8462-9775
person.identifier.ridA-3958-2010
person.identifier.scopus-author-id57207937268
person.identifier.scopus-author-id9039121900
person.identifier.scopus-author-id9435483700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication57b410e9-f6b7-42ff-ab3d-b526278715eb
relation.isAuthorOfPublication17c6b98f-4fb5-41d3-839a-6f77ec70021a
relation.isAuthorOfPublication.latestForDiscovery17c6b98f-4fb5-41d3-839a-6f77ec70021a
relation.isProjectOfPublication614ae20a-c428-4839-bc34-d052f7a358f3
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